© 1991

Cellular Aspects of Hypertension

  • Giacomo Bruschi
  • Alberico Borghetti
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XII
  2. Function and Structure of Vascular Tissue

  3. Calcium and Circulatory Control

    1. Front Matter
      Pages 59-59
    2. G. Bruschi, M. E. Bruschi, G. Regolisti, A. Borghetti
      Pages 69-78
    3. A. Gairard, R. Schleiffer, F. Pernot, C. Bergmann, B. van Overloop
      Pages 123-133
    4. J. P. Stasch, S. Kazda, G. Luckhaus, A. Knorr, B. Garthoff, C. Hirth-Dietrich
      Pages 135-147
    5. P. Pauletto, S. Sartore, G. Scannapieco, A. C. Borrione, A. M. C. Zanellato, M. Tonello et al.
      Pages 149-155
    6. P. Menè, F. Pugliese, G. A. Cinotti
      Pages 157-165
  4. Membrane Abnormalities: Blood Cell Models

    1. Front Matter
      Pages 167-167

About these proceedings


In the last two decades, investigations at the cellular level have progressively gained ground in the context of hypertension research. This choice of approach is due to some extent to the build up of know-how that molecular and cellular biology have been producing at a continuous rate. As the contents list of this volume shows, a large mass of work has been directed to gaining some insight into pathogenetic mechanisms. The pathogenesis of primary hypertension has been progressively categorized as a distinct biological problem, not amenable to the theoretical models that proved successful in understanding the nature of secondary forms of hypertension. At the same time, great efforts have been made to simplify this problem by sorting out, if possible, a few crucial mechanisms from the network of contributory factors in the regulation of blood pressure. The idea that what is to be sought is a primary structural and/or functional fault in arterial muscle has met with widespread acceptance. The strength of this argument lies in the fact that peripheral vascular resistance is increased in all forms of hypertension and, in turn, the diameter of resistance vessels is the dominant factor in the computation of total per­ ipheral resistance. On the basis of this, cardiovascular structural adaptation was proposed as a positive feedback mechanism tending to maintain hypertension, once begun, whatever the initiating factor is.


Blutdruck Hypertonie Kardiovasculäre Pharmakologie Pharmakologie artery blood pressure cardiovascular cardopvascular pharmacology cell hypertension hypertonia pathology platelet stroke tissue

Editors and affiliations

  • Giacomo Bruschi
    • 1
  • Alberico Borghetti
    • 1
  1. 1.Istituto di Clinica Medica e NefrologiaFacolta di Medicina e Chirurgia, Università degli Studi di ParmaParmaItaly

Bibliographic information

  • Book Title Cellular Aspects of Hypertension
  • Editors Giacomo Bruschi
    Alberico Borghetti
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-53987-2
  • Softcover ISBN 978-3-662-00985-7
  • eBook ISBN 978-3-662-00983-3
  • Edition Number 1
  • Number of Pages XII, 271
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Cardiology
  • Buy this book on publisher's site
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