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Artificial Liver Support

  • Book
  • © 1981

Overview

Editors:
  1. Gorig Brunner

    1. Abteilung für Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Hannover 51, Germany

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  2. Friedrich Werner Schmidt

    1. Abteilung für Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Hannover 61, Germany

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (51 chapters)

  1. Hemoperfusion

    1. Partial Hepatectomy and Subsequent Charcoal Hemoperfusion in the Conscious Rat

      • Calvin J. Ryan, James M. Courtney, Horst Klinkmann, Leslie H. Blumgart
      Pages 134-140

  2. Dialysis Procedures

    1. Large-Pore Hemodialysis in Fulminant Hepatic Failure

      • P. Opolon
      Pages 141-146

    2. Haemodialysis Procedures in Acute Liver Failure

      • A. J. Knell
      Pages 147-152

    3. Correction of Increased Plasma Amino Acid Levels by Dialysis with Amino Acid-Electrolyte-Glucose Solutions

      • H. Lösgen, E. Neumann, G. Eisenbach, F. W. Schmidt, G. Brunner
      Pages 153-158

    4. Hemofiltration in Acute Liver Failure: Substition with Electrolyte Solution Versus Normal Animal Ultrafiltrate

      • G. H. de Groot, S. W. Schalm, J. Boot, I. Schicht, P. Batavier, L. Rooke et al.
      Pages 159-163

    5. Significance of Hepatic Energy Charge and Blood Ketone Body Ratio as Criteria of Liver Support. Indication and Efficiency in Hepatectomized Patients During Cross Dialysis

      • Kazue Ozawa, Yasuo Kamiyama, Minoru Ukikusa, Takayoshi Tobe
      Pages 164-169

  3. Amino Acid Level Concentration

    1. Effect of Liver Adapted Amino Acids on Portosystemic Encephalopathy in Patients with Cirrhosis of the Liver and Portosystemic Shunts

      • P. Czygan, S. Walker, A. Sieg, A. Stiehl, G. Lanzinger, B. Kommerell
      Pages 170-171

    2. Somatostatin: A New Therapeutic Agent for Treatment of Hepatic Encephalopathy?

      • Bernd Limberg, Burkhard Kommerell
      Pages 172-174

  4. Plasmapheresis

    1. Continuous Flow Membrane Plasmapheresis Utilizing Cellulose Acetate Hollow Fiber in Hepatic Failure

      • N. Inoue, M. Yoshiba, Z. Yamazaki, T. Sakai, K. Sanjo, K. Okada et al.
      Pages 175-180

    2. Augmented Solute Reduction in Diseases Treated by Extracorporeal Detoxification Systems: X-Effect Hypothesis

      • Yukihiko Nosé, Paul S. Malchesky, Yoshihiro Asanuma
      Pages 181-188

    3. Hemoperfusion-Induced Respiratory Distress Syndrome in an Animal Model: The Effects of Corticosteroids

      • M. Luisa Zeneroli, Daniel F. Schafer, Jeanne G. Waggoner, E. Anthony Jones
      Pages 189-197

  5. Enzymatic Support

    1. Immobilized Hepatic Enzymes as a Tool in Extracorporeal Detoxification

      • L. Callegaro, E. Denti, A. Fontana
      Pages 198-201

    2. Immobilization of Ligandin on Hollow Fiber Reactors

      • L. Callegaro, A. Boniolo, A. Malinverni
      Pages 202-207

    3. Detoxification of Phenols by Sulphate Conjugation: An Alternative to Glucuronidation in an Enzymatic Liver Support System

      • Ehrhard Anhalt, Christopher J. Holloway, Gorig Brunner, Ivar Trautschold
      Pages 208-213

    4. Enzymatic Methylation of Mercaptans: Applicability in an Enzyme Reactor Liver Support System

      • Frank Tegtmeier, Christopher J. Holloway, Gorig Brunner, Ivar Trautschold
      Pages 214-218

    5. Liquid Membrane Enzyme Reactor for Artificial Liver Support

      • W. Halwachs, W. Völkel, G. Brunner, K. Schügerl
      Pages 219-229

    6. Advances in the Development of Immobilized Enzymes for Future Extracorporeal Liver Support

      • G. Brunner
      Pages 230-235

    7. A Model Enzymic Extracorporeal Detoxification System. Part II

      • J. Bohannon, L. Brinson, A. Matthews, S. S. Sofer, B. Stevens, B. Van Wie et al.
      Pages 236-246

  6. Isolated Liver Cells and Tissue

    1. Liver Assist by Cultured Cells on Artificial Capillaries

      • Carl F. W. Wolf
      Pages 247-253

    2. Hemoperfusion over Small Liver Pieces for Liver Support

      • Kenichi Kimura, Karl-Joseph Gundermann, Angelika Rasche, Tschung-Soo Lie
      Pages 254-259
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Keywords

About this book

The regenerative capacity of the liver cell is almost unlimited. Therefore after acute liver damage, be it viral, toxic, hypoxic, or surgical in origin, restitutio ad integrum is the usual outcome. In two forms of liver disease, however, this is not the case: in fulmi­ nant hepatic failure, liver regeneration often is not fast enough to keep the organism alive; in end-stage cirrhosis, regeneration is dis­ turbed by a hypertrophic architecture of fibrotic tissue. For these extreme forms of liver disease and for critical situations before and after liver surgery, artificial liver support is needed. This book contains the latest results in this area of research pre­ sented by scientists from allover the world at an international symposium held in Celle, Germany, June 2-4, 1980. Exciting new methods like continuous membrane plasma sepa­ ration and liver cell transplantation into the spleen have been de­ veloped. The older methods of hemoperfusion and dialysis have been improved. Enzymological methods and liver transplantation have made good progress. We hope that this volume will help the clinician in his decision-making and stimulate ingenious new re­ search for the benefit of our liver patients.

Editors and Affiliations

  • Abteilung für Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Hannover 51, Germany

    Gorig Brunner

  • Abteilung für Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Hannover 61, Germany

    Friedrich Werner Schmidt

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