The Barbier Reaction and Related One-Step Processes

  • Cornelis¬†Blomberg

Part of the Reactivity and Structure: Concepts in Organic Chemistry book series (REACTIVITY, volume 31)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Cornelis Blomberg
    Pages 1-13
  3. Cornelis Blomberg
    Pages 14-74
  4. Cornelis Blomberg
    Pages 75-136
  5. Cornelis Blomberg
    Pages 137-165
  6. Cornelis Blomberg
    Pages 166-183

About this book


The significant increase in applications of Barbier and Barbier-type reactions in (in-) organic synthesis over the past twenty-five years, combined with repeated stimulation on the part of Springer-Verlag (Dr. R. Stumpe) were strong in­ centives for me to write this book. My earliest activities in this field include a modest and first-ever review article (in cooperation with Dr. F. A. Hartog who at that time (1977) did his doctoral research on the Barbier reaction). References to this review article, as mentioned in the Science Citation Index till recently are a good indication for a continued interest in this simple synthetic procedure. The subtitle of this monograph, Related One-Step Processes, may require the following clarification. A synthesis with the aid of an organometallic compound is usually carried out in two steps: 1) the organometallic reagent is prepared from an organo halide and a metal in a solvent, 2) a chosen substrate is added to this reagent. In a Barbier reaction these two steps are combined: a mixture of the organo halide and the substrate is added to a suspension of the metal-in an appropriate solvent.


Organische Chemie aluminium iron lead lithium magnesium manganese metals organic chemistry organic synthesis reactant rearrangement synthesis tin zinc

Authors and affiliations

  • Cornelis¬†Blomberg
    • 1
  1. 1.AbcoudeThe Netherlands

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-85021-9
  • Online ISBN 978-3-642-85019-6
  • Series Print ISSN 0341-2377
  • Buy this book on publisher's site
Industry Sectors
Chemical Manufacturing
Consumer Packaged Goods