Skin Carcinogenesis in Man and in Experimental Models

  • Erich Hecker
  • E. G. Jung
  • F. Marks
  • W. Tilgen
Conference proceedings

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 128)

Table of contents

  1. Front Matter
    Pages I-XVIII
  2. General Aspects

    1. J. C. Barrett
      Pages 1-13
    2. L. Dagnino, J. A. Pietenpol, E. Y. Yang, H. L. Moses
      Pages 15-29
    3. R. M. Lavker, S. J. Miller, T.-T. Sun
      Pages 31-43
  3. Melanocyte Carcinogenesis

    1. C. Garbe, J. Weiß, S. Krüger, E. Garbe, P. Büttner, J. Bertz et al.
      Pages 69-89
    2. J. Weiss, C. Garbe, P. Büttner, E. G. Jung
      Pages 101-118
    3. E. H. J. Danen, G. N. P. van Muijen, P. J. M. ten Berge, D. J. Ruiter
      Pages 119-132
  4. Keratinocyte Carcinogenesis

    1. I. M. Leigh, P. E. Purkis, A. Markey, P. Collins, S. Neill, C. Proby et al.
      Pages 179-191
    2. A. J. P. Klein-Szanto, B. Ruggeri, A. Bianchi, C. J. Conti
      Pages 193-204
    3. M. Yaar, J. Arora, M. Garmyn, A. Gilani, B. A. Gilchrest
      Pages 205-214
    4. G. T. Bowden, M. A. Nelson, J. P. Levy, J. Finch, P. Krieg
      Pages 215-230
    5. J. C. van der Leun, F. R. de Gruijl, M. Tevini, R. C. Worrest
      Pages 263-267
    6. M. L. Kripke
      Pages 269-274
    7. S. H. Yuspa, K. Punnonen, E. Lee, H. Hennings, J. Strickland, C. Cheng et al.
      Pages 299-308
    8. K. Brown, C. J. Kemp, P. A. Burns, A. B. Stoler, D. J. Fowlis, R. J. Akhurst et al.
      Pages 309-321
    9. G. Fürstenberger, P. Krieg, R. Schnapke, S. Feil, F. Marks
      Pages 323-337
    10. P. Boukamp, D. Breitkreutz, A. Hülsen, S. Altmeyer, P. Tomakidi, N. E. Fusenig
      Pages 339-350
    11. D. R. Lowy, S. A. Sedman, B. D. Cohen, J. T. Schiller
      Pages 351-352
  5. Back Matter
    Pages 359-364

About these proceedings


The detection of cancer risk factors and their possible avoid­ ance would most effectively contribute to the fight against cancer. Research in these areas depends to a substantial degree on in vivo experimental animal models and on epide­ miologic studies, including data from cancer registries. When the Deutsches Krebsforschungszentrum was founded in 1964, its division "Mechanisms of Tumorigenesis" and a number of other divisions became engaged in research on chemical carcinogenesis of the skin, mainly using the mouse skin as an experimental model. Their interest orig­ inated in part from investigations of the new and at that time controversial pathogenic principle of conditional car­ cinogens as represented by certain tumor promoters which are per se noncarcinogenic. During the past 25 years, conditional carcinogens in terms of tumor promoters were established as anew, nonclassical category of cancer risk factors besides the classical solitary carcinogens. In the course of this exciting period, scientists of our center started cooperative programs with clinical dermato­ logists of the University of Heidelberg at the Clinics of Dermatology in Heidelberg and Mannheim, to extend the scope of their investigations into clinical oncology and to contribute by experimental approaches to solving problems in clinical oncology. This led to a gradual shift from mere animal studies to the more direct analyses of human tumors and opened up for us a new phase of research.


Melanocyte Cracinogenesis Melanoma Registeries Rolle von Onkogenen und Suppressionsgenen aging cancer cancer registry carcinogenesis melanoma molecular biology prevention skin skin cancer therapy tumor tumor progression

Editors and affiliations

  • Erich Hecker
    • 1
  • E. G. Jung
    • 2
  • F. Marks
    • 3
  • W. Tilgen
    • 4
  1. 1.Division: Mechanisms of Tumorigenesis, Research Program 3: Risk Factors of Cancer and Cancer PreventionDeutsches KrebsforschungszentrumHeidelbergGermany
  2. 2.Department of Dermatology, Mannheim Medical SchoolUniversity of HeidelbergMannheimGermany
  3. 3.Division: Biochemistry of Tissue Specific Regulation, Research Program 2: Tumor Cell RegulationDeutsches KrebsforschungszentrumHeidelbergGermany
  4. 4.Department of DermatologyUniversity of HeidelbergHeidelbergGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-84883-4
  • Online ISBN 978-3-642-84881-0
  • Series Print ISSN 0080-0015
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology