Adjuvant Therapy of Primary Breast Cancer

  • Hans-Jörg Senn
  • Aron Goldhirsch
  • Richard D. Gelber
  • Bruno Osterwalder
Conference proceedings

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 115)

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Biological Mechanisms and Models for New Approaches to Adjuvant Therapy of Breast Cancer

  3. Neoadjuvant (Pre- and Perioperative) Therapy

    1. J. Ragaz, J. H. Goldie, R. Baird, P. Rebbeck, V. Basco, A. Coldman
      Pages 28-35
    2. C. Jacquillat, M. Weil, G. Auclerc, M.-F. Auclerc, D. Khayat, F. Baillet
      Pages 36-42
    3. J. Houghton, M. Baum, R. Nissen-Meyer, D. Riley, R. A. Hern
      Pages 54-61
  4. Problems of Rational Follow-up and Salvage Therapy

    1. P. Valagussa, C. Brambilla, M. Zambetti, G. Bonadonna
      Pages 69-76
    2. J. M. Kurtz, J.-M. Spitalier, R. Amalric, H. Brandone, Y. Ayme, C. Bressac et al.
      Pages 77-82
    3. W. F. Jungi, A. I. Streit, L. Schmid, H.-J. Senn
      Pages 83-91
    4. J. Boyages, A. Recht, J. Connolly, S. Schnitt, M. A. Rose, B. Silver et al.
      Pages 92-102
  5. Adjuvant Therapy in Premenopausal Patients

  6. Adjuvant Therapy in Postmenopausal Patients

  7. Prognostic Factors and Treatment for Node-Negative Patients

    1. W. L. McGuire, G. M. Clark
      Pages 170-174
    2. G. Bonadonna, M. Zambetti, P. Valagussa
      Pages 175-179
    3. R. Jakesz, G. Reiner, M. Schemper, A. Reiner, G. Blijham, H. Rainer et al.
      Pages 180-185
    4. R. Nissen-Meyer, H. Høst, K. Kjellgren
      Pages 186-190
  8. Breast-Conserving Surgery and Adjuvant Radiotherapy

    1. U. Veronesi
      Pages 197-202
    2. R. Sauer, H. F. Rauschecker, A. Schauer, M. Schumacher, J. Dunst
      Pages 203-210
  9. Methodology of Adjuvant Trials and Interpretation of Results

  10. Quality of Life: Psychological Aspects of Adjuvant Therapy of Breast Cancer

  11. Back Matter
    Pages 293-296

About these proceedings


The ultimate "consumer" of the data presented at conferences on the primary treatment of operable breast cancer is the patient, and when, as in this disease, the benefits of therapy are relatively mod­ est, the availability and interpretation of the data from trials be­ comes an issue of primary importance. The effects of present treat­ ment are in fact such that more patients relapse despite therapy than are estimated to benefit from it. It is, therefore, extremely dif­ ficult for the physician to recommend unequivocally one particular adjuvant treatment modality for the vast population of women with breast cancer. The interpretation of results from clinical research-oriented pro­ grams is constantly applied, however, in the treatment of breast cancer patients outside of clinical trials. From presented or publish­ ed data, many physicians extrapolate indications for the use of a given treatment regimen for their patients, perceiving it as the "best available therapy. " It is essential that the "best available therapy" be selected individually for each patient. However, considering the modest effect of treatment upon outcome, it is imperative that those who provide the data - those who are involved in both pa­ tient care and clinical research - make it known that the best cur­ rent treatment for the population of breast cancer patients is avail­ able within the framework of clinical trials. In this way not only present-day patients but also future ones will derive the greatest benefit.


adjuvant therapy breast cancer cancer clinical trial mortality oncology radiotherapy

Editors and affiliations

  • Hans-Jörg Senn
    • 1
  • Aron Goldhirsch
    • 2
  • Richard D. Gelber
    • 3
  • Bruno Osterwalder
    • 4
  1. 1.Medizinische Klinik CKantonsspitalSt. GallenSwitzerland
  2. 2.Servizio Oncologico CantonaleOspedale CivicoLuganoSwitzerland
  3. 3.Division of Biostatistics and EpidemiologyDana-Farber Cancer InstituteBostonUSA
  4. 4.Abteilung für Hämatologie und Onkologie Medizinische Klinik CKantonsspitalSt. GallenSwitzerland

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1989
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-83339-7
  • Online ISBN 978-3-642-83337-3
  • Series Print ISSN 0080-0015
  • Buy this book on publisher's site
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Health & Hospitals
Oncology & Hematology