Structural and Functional Aspects of Enzyme Catalysis

  • Hermann Eggerer
  • Robert Huber
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-IX
  2. Mechanism of Enzyme Action

    1. Front Matter
      Pages 1-1
    2. W. N. Lipscomb
      Pages 17-23
    3. J. P. Behr, J. M. Lehn
      Pages 24-32
    4. W. Saenger
      Pages 33-42
  3. Dynamics of Molecular Recognition

  4. Function of Metals in Enzymes: Thermophilic Enzymes

    1. Front Matter
      Pages 73-73
    2. T. C. Stadtman
      Pages 96-103
    3. R. Ladenstein, O. Epp, A. Wendel
      Pages 104-113
  5. Biological and Chemical Modifications of Enzymes

  6. Selected Topics of Enzyme Catalysis

    1. Front Matter
      Pages 175-175
    2. E. E. Snell, P. A. Recsei
      Pages 177-191
    3. E. Gerlinger, W. E. Hull, J. Rétey
      Pages 196-201
  7. Back Matter
    Pages 213-218

About these proceedings


Enzymes perform the executive role in growth, energy conversion, and repair of a living organism. Their activity is adjusted to their en­ vironment within the cell, being turned off, switched on, or finely tuned by specific metabolites according to demands at the physiologi­ cal level. Each enzyme discovered in the long history of enzymology has revealed its own individuality. Even closely related members of a family differ in specificity, stability or regulatory properties. Despite these, at first sight overwhelming aspects of individuality, common factors of enzymic reactions have been recognized. Enzymes are stereospecific catalysts even when a nonspecific process would yield the same product. Knowledge of the detailed stereochemistry of an enzymic reaction helps to deduce reaction mechanisms and to ob­ tain insight into the specific binding of substrates at the active site. This binding close to catalytically competent groups is related to the enormous speed of enzyme-catalyzed reactions. The physical ba­ sis of rate-enhancement is understood in principle and further exploit­ ed in the design of small organic receptor molecules as model enzymes. These aspects of enzyme catalysis are discussed in Session 1. Session 2 emphasizes the dynamic aspects of enzyme substrate inter­ action. Substrate must diffuse from solution space to the enzyme's surface. This process is influenced and can be greatly facilitated by certain electrostatic propterties of enzymes. The dynamic events during catalysis are studied by relaxation kinetics or NMR techniques.


Enzym catalysis enzyme enzymes receptor

Editors and affiliations

  • Hermann Eggerer
    • 1
  • Robert Huber
    • 2
  1. 1.Physiologisch-Chemisches InstitutTechnische UniversitätMünchen 40Germany
  2. 2.Max-Planck-Institut für BiochemieMartinsriedGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1981
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-81740-3
  • Online ISBN 978-3-642-81738-0
  • Series Print ISSN 0366-5887
  • Buy this book on publisher's site
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