Adjuvant Therapies of Cancer

  • G. Mathé
  • G. Bonadonna
  • S. Salmon

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 80)

Table of contents

  1. Front Matter
    Pages I-XVI
  2. General Considerations

    1. F. Spreafico, A. Mantovani, R. Giavazzi, G. Conti, A. Anaclerio
      Pages 1-8
    2. A. M. Neville
      Pages 17-21
  3. Hemopoietic and Lymphoid Neoplasias

    1. M. Weil, C. Jacquillat, M. F. Auclerc, G. Schaison, C. Chastang, J. Bernard
      Pages 36-41
    2. R. Favre, G. Sebahoun, D. Bagarry-Liégey, C. Imbert, P. Ciardelli, J. A. Gastaut et al.
      Pages 56-63
    3. M. Lehtinen, P. Ahrenberg, A. Hänninen, E. Ikkala, R. Lahtinen, A. Levanto et al.
      Pages 70-72
    4. P. N. Grozea, E. J. De Persio, C. A. Coltman Jr., C. J. Fabian, F. S. Morrison, E. A. Gehan et al.
      Pages 83-91
    5. B. Hœrni, M. Durand, H. Eghbali, G. Hœrni-Simon, P. Richaud, A. de Mascarel
      Pages 92-97
  4. Bone Tumors

    1. E. van der Schueren, K. Breur
      Pages 98-102
    2. H. Strander, T. Aparisi, H. Blomgren, L. Å. Broström, K. Cantell, S. Einhorn et al.
      Pages 103-107
    3. M. Gasparini, F. Lombardi
      Pages 120-123
    4. D. K. Hossfeld, S. Seeber, E. Siemers, C. G. Schmidt, E. Scherer
      Pages 124-127
  5. Breast Carcinoma

    1. S. Gore, A. Langlands, S. Pocock, G. Kerr
      Pages 134-141
    2. R. Nissen-Meyer, K. Kjellgren, B. Mansson
      Pages 142-148
    3. G. Bonadonna, P. Valagussa, A. Rossi, G. Tancini, C. Brambilla, S. Marchini et al.
      Pages 149-156
    4. R. B. Weiss, D. C. Tormey, F. Holland, V. E. Weinberg, G. Lesnick, M. Perloff et al.
      Pages 170-176
    5. H. J. Senn, R. Amgwerd, W. F. Jungi, R. Hochuli, J. Ammann, G. Engelhart et al.
      Pages 177-184
    6. M. Betzler, W. Schreml, M. Lang, H. P. Lohrmann, H. D. Flad, P. Schlag et al.
      Pages 185-191
    7. F. Lacour, J. Lacour, A. Spira, M. Michelson, G. Delage, J. Y. Petit et al.
      Pages 200-206
  6. Lung Carcinoma

  7. Melanoma

  8. Testicular Neoplasia

    1. C. G. Schmidt
      Pages 269-276
  9. Gastrointestinal Neoplasms

    1. P. Schlag, W. Schreml, W. Gaus, C. Herfarth, M. M. Linder, W. Queisser et al.
      Pages 277-283
    2. J. S. Macdonald, D. G. Haller, D. L. Kisner
      Pages 284-290
    3. C. Gisselbrecht, D. Belpomme, L. Mignot, M. Marty, G. Mathé, M. Boiron
      Pages 296-302
  10. Conclusions and Prospects

    1. F. Volterrani, D. Sigurtà
      Pages 309-311

About this book


Transplantation of syngeneic (donor is a monozygous twin) or allogeneic (donor is an HLA-identical sibling) marrow provides the opportunity for aggressive antileukemic therapy without regard to marrow toxicity. Until 1975, marrow transplantation was carried out only after failure of all other therapy. Consequently, most patients were in advanced relapse. Six of 16 recipients of syngeneic marrow and 13 of 100 recipients of allogeneic marrow are still in remission after 5. 5-10 years [3, 7]. An actuarial survival curve of the first 100 patients grafted in Seattle after conditioning with cyclophos­ phamide (60 mg/kg on each of 2 successive days) and total body irradiation (1,000 rad) showed three periods of interest: (1) The first 4 months showed a rapid loss of patients associated with advanced illness, graft-versus-host disease, infections (in particular interstitial pneumonias), and recurrent leukemia; (2) from 4 months to 2 years, the curve showed a much slower rate of decline attributable primarily to recurrent leukemia; and (3) from 2-10 years, the curve was almost flat with a negligible loss of patients and no recurrent leukemia. This flat portion of the curve corresponded to 13% of the patients and indicates a strong probability that the majority of these survivors are cured of their disease [8]. Attempts at reducing the incidence of leukemic relapse after transplantation were made by a number of marrow transplant groups by added chemotherapy.


Immunotherapie Krebs Strahlentherapie Zytostatikum cancer chemotherapy leukemia radiation transplantation

Editors and affiliations

  • G. Mathé
    • 1
  • G. Bonadonna
    • 2
  • S. Salmon
    • 3
  1. 1.Institut de Cancérologie et d’ImmunogénétiqueHôpital Paul-BrousseVillejuifFrance
  2. 2.Istituto Nazionale per lo Studio e la Cura dei TumoriMilanItaly
  3. 3.Health Science Center Department of Internal Medicine Section of Hematology and Oncology TucsonThe University of ArizonaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1982
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-81687-1
  • Online ISBN 978-3-642-81685-7
  • Series Print ISSN 0080-0015
  • Buy this book on publisher's site
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