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Chemical Recognition in Biology

  • F. Chapeville
  • A.-L. Haenni
Book

Part of the Molecular Biology, Biochemistry and Biophysics book series (MOLECULAR, volume 32)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Recognition of Ligands — Enzymic Catalysis

  3. Enzyme Regulation

    1. Front Matter
      Pages 111-111
    2. D. E. Koshland Jr., M. J. Anderson
      Pages 136-143
    3. E. R. Stadtman, R. J. Hohman, J. N. Davis, M. Wittenberger, P. B. Chock, S. G. Rhee
      Pages 144-156
    4. B. Hess, A. Boiteux, E. M. Chance
      Pages 157-164
    5. S. Ebashi, Y. Nonomura, K. Kohama, T. Kitazawa, T. Mikawa
      Pages 183-194
    6. M. S. Bretscher
      Pages 195-196
    7. J. Sy
      Pages 197-204
  4. Nucleic Acid — Protein Interactions; Mutagenesis

  5. Protein Biosynthesis

    1. Front Matter
      Pages 331-331
    2. H. Grosjean, H. Chantrenne
      Pages 347-367
    3. W. Wintermeyer, J. M. Robertson, H. G. Zachau
      Pages 368-375
    4. H. G. Wittmann
      Pages 376-397
  6. Philosophical Reflexions

  7. Back Matter
    Pages 431-432

About this book

Introduction

Studies of chemical recognition in biology were initiated about half a century ago with the flrst kinetic data obtained on enzyme catalysis and inhibition. They led to a rather static representation of the recognition process illustrated by the lock and key model that still continues to influence our overall image of recognition and its specificity. In several cases, crystallographic studies of enzyme-substrate complexes have supported this model. Indeed, in a crystallized ligand-enzyme complex, a close fltting is observed between the active center of the enzyme and the functional groups of the ligand. How­ ever, this does not necessarily result from a direct recognition process between rigid structures, but may result from a progressive adaptation during which the initial struc­ tures of the enzyme and the ligand are modified (induced-flt mechanism). Recently, a great deal of work has been devoted to the study of recognition in more complex systems such as the replication or the translation machin~ries; clearly, the extraordinary precision of such systems cannot be explained solely in terms of physical matching between enzymes and their substrates. This has led to a noticeable change of perspective in these areas. As a result of the new kinetic viewpoint, one rather focuses on the time-course of the processes, on the kinetic balance between steps of the reaction, on the energy-accuracy relationships and on the strategies which permit the achievement of high precision using relatively error-prone components in an appropriate dynamic interplay.

Keywords

Eiweisssynthese Enzymatische Regulation adaptation biology enzymes translation

Editors and affiliations

  • F. Chapeville
    • 1
  • A.-L. Haenni
    • 1
  1. 1.CNRS, Inst. de recherche en biologie moléculaireUniversité Paris VIIParis Cedex 05France

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-81503-4
  • Copyright Information Springer-Verlag Berlin Heidelberg 1980
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-81505-8
  • Online ISBN 978-3-642-81503-4
  • Series Print ISSN 0077-0221
  • Buy this book on publisher's site