Lymphoid Neoplasias II

Clinical and Therapeutic Aspects

  • Georges Mathé
  • Maxime Seligmann
  • Maurice Tubiana

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 65)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Clinical Aspects: Staging and Therapeutic Implications

    1. Front Matter
      Pages 1-1
    2. M. Tubiana
      Pages 3-4
    3. G. Bonadonna, R. Castellani, C. Narduzzi, P. Spinelli, F. Rilke
      Pages 41-50
    4. S. A. Rosenberg, M. Ribas-Mundo, D. R. Goffinet, H. S. Kaplan
      Pages 51-57
    5. J. Brugere, J. Dumont, C. Jaulerry, G. Schwaab
      Pages 58-62
    6. B. Longpre, J. Lamarche, M. Rochon, M. Lepine
      Pages 81-87
    7. G. Mathé, J. L. Misset, M. Gil-Delgado, M. Delgado, F. De Vassal
      Pages 88-107
  3. Treatment of Non-Hodgkin’s Lymphomas

    1. Front Matter
      Pages 109-109
    2. B. Van Der Werf-Messing
      Pages 111-128
    3. J. J. Sotto, M. Michallet, M. F. Sotto, B. Lachet, H. Martin, R. Schaerer et al.
      Pages 149-159
    4. B. Hœrni, M. Durand, A. de Mascarel, P. Richaud, G. Hœrni-Simon, J. Chauvergne et al.
      Pages 160-163
    5. J. P. Le Bourgeois, M. Meignan, P. Lasser, C. Parmentier, F. Pene, M. Tubiana
      Pages 170-180
    6. C. Parmentier, D. Maraninchi, N. Morardet, J. P. Droz, P. Charbord
      Pages 181-187
    7. S. K. Carter
      Pages 214-217
  4. Back Matter
    Pages 219-220

About this book


We have studied 24 cases of secondarily leukemic (stage V) lymphosarcoma (LS), 31 cases of "d'emblee" leukemic LS, and ten cases of lymphoid leukemic neoplasias transitional between "d'emblee" leukemic LS and chronic lymphocytic leukemia (eLL). These cases only concern the common types ofthe WHO classification ofLS, i.e., the prolymphocytic, the lymphoblastic, and the immunoblastic. Some cases have also been classified by cell surface markers. The secondarily leukemic conversion occurred in 40% of the lymphoblastic types, in 14% of the prolymphocytic types, and in 17% of the immunoblastic types. It never occurred at stage I but could occur after any other stage. The mediastinal involvement was observed in three types, but most often in the lymphoblastic type. The prognosis after an acute lymphoid leukemia (ALL) treatment comprising active immunotherapy following chemo(radio)therapy is better for the leukemic prolymphocytic and lymphoblastic LS than for the immunoblastic type. Two patients (one of the lymphoblastic type) are in complete remission after 8 and 5 years, respectively. We have described ten cases of "d'emblee" leukemic LS with either large lymphoid or extra­ lymphoid masses, bone marrow leukemic cell involvement, and LS aspects of neoplastic cells. Mediastinal, abdominal, or other tumor masses are frequent.


cell classification immunotherapy leukemia neoplasm therapy tumor

Editors and affiliations

  • Georges Mathé
    • 1
  • Maxime Seligmann
    • 2
  • Maurice Tubiana
    • 3
  1. 1.Institut de Cancérologie et d’ImmunogénétiqueHôpital Paul-BrousseVillejuifFrance
  2. 2.Laboratory of Immunochemistry and Immunopathology INSERM (U 108), and Laboratory of Cytology Research Institute on Blood DiseasesHôpital Saint-LouisParisFrance
  3. 3.Department of RadiationInstitut Gustave-RoussyVillejuifFrance

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1978
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-81251-4
  • Online ISBN 978-3-642-81249-1
  • Series Print ISSN 0080-0015
  • Buy this book on publisher's site
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