Attempts to Understand Metastasis Formation III

Therapeutic Approaches for Metastasis Treatment

  • Ursula Günthert
  • Peter M. Schlag
  • Walter Birchmeier

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 213/3)

Table of contents

  1. Front Matter
    Pages I-XV
  2. R. A. Reisfeld, S. D. Gillies
    Pages 27-53
  3. J. A. Hendrzak, M. J. Brunda
    Pages 65-83
  4. Lea Eisenbach
    Pages 85-100
  5. M. S. Sy, D. Liu, R. Schiavone, J. Ma, H. Mori, Y. Guo
    Pages 129-153
  6. R. Ristamäki, H. Joensuu, S. Jalkanen
    Pages 155-166
  7. R. Alessandro, J. Spoonster, R. P. Wersto, E. C. Kohn
    Pages 167-188
  8. V. Schirrmacher, V. Umansky, M. Rocha
    Pages 189-216
  9. P. M. Schlag, M. Hünerbein, P. Hohenberger
    Pages 241-255
  10. Back Matter
    Pages 257-264

About this book


In metastasis, tumor cells disseminate from the primary lesion and home to secondary organs where they may remain dormant for a long time. Metastasis formation is still the most feared manifestation for tumor patients and clinicians. Although improvements have been made concerning earlier detection and specific therapy, most of the cancer patients still die of distant metastases. The purpose of these three volumes is to review the recent progress in molecular metas­ tasis research and to attempt to further understand the biol­ ogy of this multifocal process. With respect to present day molecular biology, the pioneers of metastasis research established the basic concepts of metasta­ sis formation in the 1970s and 1980s, namely, clonal selection of metastatic cells, heterogeneity of metastatic subpopulations, organ specificity of metastasis and the importance of angio­ genesis (Fidler, Kripke, Nicolson, Folkman and others). In the 1980s and 1990s, several of the molecules involved were identified and their network interactions elucidated. These three volumes of Current Topics in Microbiology and Immuno­ logy compile the most recent developments on these meta­ stasis-related molecules; their interactions, regulation, and ways to interfere with their action. It became evident that metastasis-related molecules are confined to distinct cellular compartments, such as the extracellular space, the cell membrane, the cytoplasmic signalling network, and the nuclear regulatory system. For the complex metastatic cascade, proteolysis and alterations in adhesive functions are the most obvious and thus one of the most thoroughly investigated processes.


Geschwulst Krebs Krebstherapie angiogenesis cell cytokine cytokines gene gene therapy immunotherapy metastasis molecular biology regulation tumor tumor progression

Editors and affiliations

  • Ursula Günthert
    • 1
  • Peter M. Schlag
    • 2
  • Walter Birchmeier
    • 3
  1. 1.Basel Institute for ImmunologyBaselSwitzerland
  2. 2.Virchow Klinikum, Chirurgische Abteilung, Robert-Rössle-KlinikMax-Delbrück-Centrum BerlinBerlinGermany
  3. 3.Max-Delbrück-Centrum für Molekulare MedizinBerlinGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1996
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-80073-3
  • Online ISBN 978-3-642-80071-9
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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