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An Antigen Depository of the Immune System: Follicular Dendritic Cells

  • Marie H. Kosco-Vilbois

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 201)

Table of contents

  1. Front Matter
    Pages I-IX
  2. A. K. Szakal, Z. F. Kapasi, S. T. Haley, J. G. Tew
    Pages 1-13
  3. E. Heinen, A. Bosseloir, F. Bouzahzah
    Pages 15-47
  4. T. K. Van den Berg, K. Yoshida, C. D. Dijkstra
    Pages 49-67
  5. A. S. Freedman, D. Wang, J. Scott Phifer, S. N. Manie
    Pages 83-92
  6. J. G. Tew, G. F. Burton, S. Helm, J. Wu, D. Qin, E. Hahn et al.
    Pages 93-104
  7. G. Grouard, O. de Bouteiller, C. Barthelemy, S. Lebecque, J. Banchereau, Y.-J. Liu
    Pages 105-117
  8. K. Maeda, M. Matsuda, Y. Imai
    Pages 119-139
  9. H.-J. Schuurman, P. Joling, D. F. van Wichen, L. H. P. M. Rademakers, R. Broekhuizen, R. A. de Weger et al.
    Pages 161-188
  10. Back Matter
    Pages 205-212

About this book

Introduction

Follicular dendritic cells (FOe) are unique among cells of the immune system. While their morphological characteristics re­ sulted in their inclusion as a 'dendritic cell type', tt1ey differ quite significantly from the other members of the dendritic cell family. In contrast to T-cell-associated dendritic cells or the Langerhans cells found in the skin, FOe reside in highly organized B cell follicles within secondary lymphoid tissues. This site of resi­ dence provided a nomenclature committee in 1982 with the second descriptive factor for the derivation of their name. The cardinal feature of FOe is to trap and retain antigen on the surface of their dendritic processes for extended amounts of time and it is this feature that provides the conceptual compo­ nent for the title of this book. In response to an antigenic challenge, primary B cell follicles undergo dynamic events, giving rise to germinal centers which are associated with activation, expansion, and differentiation processes of B cells. The interactions of B cells with Foe and T cells in the germinal centers are essential for generating the complete repertoire of antibody isotypes obtained during an antibody response. In addition, stimuli either initiated or main­ tained during the germinal center reponse leads to production of high affinity antibodies through the processes of somatic muta­ tion and clonal selection. In this context, FOe act as a pivotal source of antigen. They accumulate foreign proteins (e. g.

Keywords

AIDS HIV T cell antibody antigen cell cytokine growth immune response immune system immunodeficiency infection pathology tissue virus

Editors and affiliations

  • Marie H. Kosco-Vilbois
    • 1
  1. 1.Glaxo Institute for ImmunologyPlan-les-Ouates GenevaSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-79603-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-79605-0
  • Online ISBN 978-3-642-79603-6
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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