• Rainer F. Greger
  • H. Knauf
  • E. Mutschler

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 117)

Table of contents

  1. Front Matter
    Pages I-XXI
  2. B. Kaissling, J. Dørup
    Pages 1-66
  3. F. Lang, A. Busch
    Pages 67-114
  4. W. G. Guder, M. Schmolke
    Pages 115-140
  5. H.-J. Lang, M. Hropot
    Pages 141-172
  6. W. Möhrke, F. Ullrich
    Pages 173-200
  7. R. Greger
    Pages 221-274
  8. H. Velázquez, H. Knauf, E. Mutscler
    Pages 275-334
  9. H. Endou, M. Hosoyamada
    Pages 335-361
  10. L. G. Palmer, T. R. Kleyman
    Pages 363-394
  11. T. Netzer, F. Ullrich, H. Knauf, E. Mutschler
    Pages 395-421
  12. O. S. Better, I. Rubinstein, J. Winaver
    Pages 423-441
  13. J. B. Puschett
    Pages 443-505
  14. Back Matter
    Pages 507-517

About this book


The first edition of this handbook appeared exactly twenty-five years ago. Due to enormous changes in the area of diuretics, the second edition has had to be completely revised. Substantial progress has been made in the functional anatomy of the kidney and in the concepts of how substances and ions are specifically transported across the various nephron segments. No one could have foreseen twenty-five years ago that the late 1980s and the early 1990s have provided us with methodologies to study transport events not only at the single cell level, but even at the level of the single transporter molecule. Many of the transporters for ions and organic substances have been cloned meanwhile by the new methods of molecular biology, and their function can be described more precisely by new transport studies such as the patch-clamp technique. These new insights have also led to a new understanding of how the currently used diuretics act. Just a few months ago, the Na+Cl- co-transporter, which is the target of thiazides, the Na+2CI-K+ co-transporter, which is the target of furosemide, and the amiloride sensitive Na+ channel were cloned. Hence, the targets of diuretics have now been identified at the molecular level. In addition, during the past twenty-five years extensive studies have been performed on the pharmacokinetics of diuretics. We have learned how changes in liver metabolism and altered renal excretion influence the pharmacology of this class of compounds.


Clinical Usage Diuretics Diuretikum Hemmstoffe Pharmakodynamik Pharmakokinetik Tabule Transport Transport Inhibitors drug kinetics pharmacodynamics pharmacokinetics

Editors and affiliations

  • Rainer F. Greger
    • 1
  • H. Knauf
    • 2
  • E. Mutschler
    • 3
  1. 1.Physiologisches Institutder Albert-Ludwigs-Universität FreiburgFreiburgGermany
  2. 2.Medizinische Klinik I Gastroenterologie-Kardiologie-NephrologieSt. Bernward Krankenhaus HildesheimHildesheimGermany
  3. 3.Pharmakologisches Institut für NaturwissenschaftlerBiozentrum NiederurselFrankfurtGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-79567-1
  • Online ISBN 978-3-642-79565-7
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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