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Immediate-Early Genes in the Central Nervous System

  • T. R. Tölle
  • J. Schadrack
  • W. Zieglgänsberger

Table of contents

  1. Front Matter
    Pages i-vii
  2. S. P. Hunt, L. A. McNaughton, R. Jenkins, W. Wisden
    Pages 18-34
  3. T. R. Tölle, J. Schadrack, J. M. Castro-Lopes, W. Zieglgänsberger
    Pages 51-77
  4. J. Kraus, B. Bacher, X. Wang, V. Höllt
    Pages 104-115
  5. G. Kasof, T. Curran, J. I. Morgan
    Pages 116-131
  6. Back Matter
    Pages 161-166

About this book

Introduction

Immediate-early genes are believed to be involved in the neuron's ability to con­ vert short-term synaptic stimulation into long-lasting responses and thus contribute to the adaptive alterations involved in neuronal plasticity. Cellular immediate-early genes share a close structural homology with some viral oncogenes. Recent advances in cellular biology have identified the activation and deactivation of immediate-early genes as molecular mechanisms to control regulated and deregulated growth, cellular differentiation and development. In this view immediate-early genes may function as third messengers in a stimulus­ transcription cascade transferring extracellular information into changes in target­ gene transcription, thereby changing the phenotype of neurons. Immediate-Early Genes in the Central Nervous System provides a comprehensive up-to-date overview of current methodology in the research of immediate-early genes and includes a wide range of neurobiological topics, such as regeneration, memory formation, epilepsia and nociception. The contributors to this book have been selected from among the leading experts in their field of research. T.R. TOLLE J. SCHADRACK W. ZIEGLGANSBERGER Contents Immediate-early genes -how immmediate and why early? G./. Evan .............................................. . Immediate-early gene activation as a window on mechanism in the nervous system S.P. Hunt, L.A. McNaughton, R. Jenkins, and W. Wisden. . . . . . . . . .. . . . 18 of immediate-early genes during Differential expression synaptic plasticity, seizures and brain injury suggests specific functions for these molecules in brain neurons M. Dragunow . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . 35 . . . . . . . . . .

Keywords

Genes activation biological gene memory formation nervous system nervous systems neurons nociception proteins regeneration transcription transgenic anmals

Editors and affiliations

  • T. R. Tölle
    • 1
  • J. Schadrack
    • 1
  • W. Zieglgänsberger
    • 1
  1. 1.Max-Planck-Institut für Psychiatrie Klinisches InstitutKlinische NeuropharmakologieMünchenGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-79562-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-79564-0
  • Online ISBN 978-3-642-79562-6
  • Buy this book on publisher's site
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