Alzheimer’s Disease: Lessons from Cell Biology

  • K. S. Kosik
  • D. J. Selkoe
  • Y. Christen

Part of the Research and Perspectives in Alzheimer’s Disease book series (ALZHEIMER)

Table of contents

  1. Front Matter
    Pages I-XIX
  2. E. Grote, F. Bonzelius, G. Herman, M. Ramaswami, J. van de Goor, S. Green et al.
    Pages 1-13
  3. I. Mellman, K. Matter, E. Yamamoto, N. Pollack, J. Roome, K. Felsenstein et al.
    Pages 14-26
  4. L. Hendriks, P. Cras, J.-J. Martin, C. Van Broeckhoven
    Pages 37-48
  5. B. De Strooper, D. Moechars, K. Lorent, I. Dewachter, F. Van Leuven
    Pages 49-65
  6. B. Allinquant, P. Hantraye, C. Bouillot, K. L. Moya, A. Prochiantz
    Pages 66-69
  7. M. H. Cobb, J. E. Hepler, E. Zhen, D. Ebert, M. Cheng, A. Dang et al.
    Pages 78-87
  8. E.-M. Mandelkow, J. Biernat, B. Lichtenberg-Kraag, G. Drewes, H. Wille, N. Gustke et al.
    Pages 103-120
  9. V. Buée-Scherrer, L. Buée, P. R. Hof, P. Vermersch, B. Leveugle, A. Wattez et al.
    Pages 132-149
  10. J. Hugon, P. Sindou, M. Lesort, P. Couratier, F. Esclaire, C. Yardin
    Pages 172-179
  11. D. W. Cleveland, Z. Xu
    Pages 180-192
  12. N. Heintz, L. Feng, J. Gubbay, S. Cheng, J. Zuo, P. L. De Jager et al.
    Pages 193-201
  13. B. Brugg, Y. Lemaigre-Dubreuil, G. Huber, B. Kopmels, N. Delhaye-Bouchaud, E. E. Wollman et al.
    Pages 202-216
  14. J. B. Davis, C. Behl, F. G. Klier, D. Schubert
    Pages 217-229
  15. K. S. Kosik, A. Ferreira, R. Knowles, N. Leclerc, S. M. Greenberg
    Pages 230-240
  16. Back Matter
    Pages 241-243

About these proceedings


Like the unflinching gaze of Captain Ahab walking the deck of the Pequod, Alzheimer researchers have had their sights fixed firmly on the disease for many years. Now, as this volume amply demonstrates, accomplished researchers from other fields, who have thought deeply about cell biological problems are applying their insights to Alzheimer's disease. The contri­ butions here represent the text versions of the proceedings from the tenth "Colloque medecine et recherche" of the Fondation IPSEN devoted to research on Alzheimer's disease. The symposium, entitled "Alzheimer's Disease: Lessons from Cell Biology" was held in Paris on April 25, 1994. As is apparent from the varied backgrounds of the contributors, the scientific pursuit of Alzheimer's disease has begun to meld with more basic disciplines, particularly cell biology. While on the one hand, new areas of specialization are continuously emerging, the boundaries of older disciplines are increas­ ingly blurred. Perhaps for most of the years since the first descriptions of the disease in 1907, the science of Alzheimer's disease was descriptive, and lay in the province of pathologists. This time period, during which a great deal was learned about the topography of senile plaques and neurofibrillary tangles, culminated with an ultrastructural description of these hallmark structures. The modern era of Alzheimer's disease research opened with the iden­ tification of the component proteins in plaques and tangles.


Alzheimer Hemorrhagic Stroke aging alzheimer's disease amyloid precursor protein biology cell cell biology cellular processes neurodegenerative disorders proteins

Editors and affiliations

  • K. S. Kosik
    • 1
  • D. J. Selkoe
    • 1
  • Y. Christen
    • 2
  1. 1.Harvard Medical SchoolBrigham and Women’s HospitalBostonUSA
  2. 2.Fondation IPSENParisFrance

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-79425-4
  • Online ISBN 978-3-642-79423-0
  • Series Print ISSN 0945-6066
  • Buy this book on publisher's site
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