© 1995

Toxicology of Metals

Biochemical Aspects

  • Robert A. Goyer
  • M. George Cherian

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 115)

Table of contents

  1. Front Matter
    Pages I-XXII
  2. L. Pelletier, P. Druet
    Pages 77-92
  3. J. Koropatnick, M. E. I. Leibbrandt
    Pages 93-120
  4. E. H. Jeffery
    Pages 139-161
  5. K. Miura, A. Naganuma, S. Himeno, N. Imura
    Pages 163-187
  6. P. L. Goering, M. P. Waalkes, C. D. Klaassen
    Pages 189-214
  7. E. J. O’Flaherty
    Pages 215-228
  8. P. L. Goering, B. R. Fisher
    Pages 229-266
  9. J. S. Lazo
    Pages 267-278
  10. J. Zeng, J. H. R. Kägi
    Pages 333-347
  11. T. G. Rossman
    Pages 373-405
  12. M. Styblo, M. Delnomdedieu, D. J. Thomas
    Pages 407-433

About this book


The toxicology of metals has been concerned in the past with effects that produced clinical signs and symptoms. However, this view of metal toxicology has expanded in recent years due principally to two advances. There has been a considerable increase in our knowledge of the biochemical effects of metals. In addition, biomarkers of toxicity can now be recognized that identify toxicity at levels of exposure that do not produce overt clinical effects. Thus, the toxicology of metals is now focused on nonclinical events that reflect adverse health effects. This new awareness has produced the challenge of determining the lowest adverse level of exposure. With increasing analytical sensitivity and methodologies to detect small changes at the molecular level, the lowest level of exposure of some toxic metals, like lead, is very small. Indeed, for metals in which there is no biologic requirement, it may be questioned whether there is a level of exposure that does not produce some degree of toxicity. For essential metals, the question is being asked as to the levels at which exposure exceeds biologic require­ ments and excess exposure becomes toxic. The appropriateness of health decisions and the formation of public policy are dependent on the availability of current scientific information that addresses these questions. The information in this volume is intended to be a resource for this purpose as well as a reference for students of toxicology and other health professionals.


Chelate Metal Chelation Metalle Toxic Metals Toxikologie chromium gene expression health effects human health mercury mutagenesis poison resistance toxicity toxicology

Editors and affiliations

  • Robert A. Goyer
    • 1
  • M. George Cherian
    • 1
  1. 1.Department of PathologyUniversity of Western OntarioCanada

Bibliographic information

  • Book Title Toxicology of Metals
  • Book Subtitle Biochemical Aspects
  • Editors Robert A. Goyer
    M. George Cherian
  • Series Title Handbook of Experimental Pharmacology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-58281-6
  • Softcover ISBN 978-3-642-79164-2
  • eBook ISBN 978-3-642-79162-8
  • Series ISSN 0171-2004
  • Series E-ISSN 1865-0325
  • Edition Number 1
  • Number of Pages XXII, 467
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Pharmacology/Toxicology
    Biochemistry, general
    Internal Medicine
  • Buy this book on publisher's site
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