GTPases in Biology II

  • Burton F. Dickey
  • Lutz Birnbaumer

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 108 / 2)

Table of contents

  1. Front Matter
    Pages I-XL
  2. Signal Transduction by Trimeric G Proteins

    1. Front Matter
      Pages 1-1
    2. Cellular Architecture and its Role in Signal Transduction

    3. G-Protein Coupled Receptors

    4. Trimeric G-Proteins

    5. Effectors of G-Proteins

      1. R. T. Premont, J. Chen, O. Jacobowitz, R. Iyengar
        Pages 189-212
      2. F. Hofmann, M. Biel, E. Bosse, R. Hullin, P. Ruth, A. Welling et al.
        Pages 225-238
      3. P. Gierschik, M. Camps
        Pages 251-264
    6. Specialized Systems

      1. K. P. Hofmann
        Pages 267-290
      2. G. Szabo, Y. Li, A. S. Otero
        Pages 291-302
      3. K. Clark, M. Whiteway
        Pages 303-318
      4. M. Forte, F. Quan, D. Hyde, W. Wolfgang
        Pages 319-334
      5. L. Wu, C. Gaskins, R. Gundersen, J. A. Hadwiger, R. L. Johnson, G. S. Pitt et al.
        Pages 335-349
      6. K. R. McLeish, K. H. Jakobs
        Pages 363-373
      7. A. J. Morris, D. H. Maurice, G. L. Waldo, J. L. Boyer, T. K. Harden
        Pages 401-415
      8. P. Brabet, V. Homburger, J. Bockaert
        Pages 429-446
      9. S. D. Kroll, R. Iyengar
        Pages 471-484
      10. L. Birnbaumer
        Pages 527-546
      11. U. Panten, C. Schwanstecher, M. Schwanstecher
        Pages 547-559
  3. Back Matter
    Pages 611-618

About this book


Recent advances in molecular biology have shown GTPases and phosphoproteins to be the paramount molecular switches uti- lized intracellularly in biological systems. The origins of the GTPase switch appear to be almost as ancient as life it- self, and through evolution nature has adapted this switch to a variety of purposes. In this two-volume work a broad survey of the major classes of GTPases is presented. The role of GTPases in ensuring ac- curacy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle transfer, GTPases which activate GTPases during nascent protein translocation, and the many roles of ras-related proteins in growth, cytoskeletal polymerization, and vesicle transfer, are all described in 80 chapters by the leading authorities in their fields. Both detailed knowledge of specific systems or proteins and general principles of structure and function are offered. Much of this information has never been published before. At the rate the extended family of GTPases is growing it becomes increasingly unlikely that we will again get it to sit for a group portrait such as this. Therefore, the volume has the chance to become t h e reference work for GTPases.


Calcium DNA Nucleotide antibody biology kidney metabolism molecular biology morphogenesis mutation neurotransmitter protein proteins transcription translation

Editors and affiliations

  • Burton F. Dickey
    • 1
  • Lutz Birnbaumer
    • 2
  1. 1.Baylor College of Medicine, Department of Medicine Cell Biology and Experimental TherapeuticsHouston VA Medical CenterHoustonUSA
  2. 2.Department of Cell Biology, Molecular Physiology and Biophysics, Medicine and NeurosciencesBaylor College of MedicineHoustonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-78347-0
  • Online ISBN 978-3-642-78345-6
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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