© 1993

GTPases in Biology I

  • Burton F. Dickey
  • Lutz Birnbaumer

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 108 / 1)

Table of contents

  1. Front Matter
    Pages I-XLIII
  2. Biological Importance of GTPase-Driven Switches

  3. Structures of the GTPase Switches

    1. Front Matter
      Pages 113-113
    2. J. Cavallius, W. C. Merrick
      Pages 115-130
    3. H. Itoh, Y. Kaziro
      Pages 131-149
    4. S.-H. Kim, G. G. Privé, M. V. Milburn
      Pages 177-194
    5. A. Wittinghofer, E. F. Pai, R. S. Goody
      Pages 195-211
    6. S. L. Campbell-Burk, T. E. Van Aken
      Pages 213-234
    7. C. K. Foley, L. G. Pedersen, T. A. Darden, P. S. Charifson, A. Wittinghofer, M. W. Anderson
      Pages 235-245
  4. Small Ras-Related GTpases

    1. Front Matter
      Pages 247-247

About this book


Recent advances in molecular biology have shown GTPases and phosphoproteins to be the paramount molecular switches utilized intracellularly in biological systems. The origins of the GTPase switch appear to be almost as ancient as life itself, and through evolution nature has adapted this switch to a variety of purposes. In this two-volume work a broad survey of the major classes of GTPases is presented. The role of GTPases in ensuring accuracy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle transfer, GTPases which activate GTPases during nascent protein translocation, and the many roles of ras-related proteins in growth, cytoskeletal polymerization, and vesicle transfer, are all described in 80 chapters by the leading authorities in their fields. Both detailed knowledge of specific systems or proteins and general principles of structure and function are offered. Much of this information has never been published before. At the rate the extended family of GTPases is growing it becomes increasingly unlikely that we will again get it to sit for a group portrait such as this. Therefore, the volume has the chance to become the reference work for GTPases.


Calcium DNA Nucleotide RNA biochemistry biology gene expression membrane transport metabolism molecular biology mutation protein protein synthesis proteins translation

Editors and affiliations

  • Burton F. Dickey
    • 1
  • Lutz Birnbaumer
    • 2
  1. 1.Department of Medicine, Cell Biology and Experimental Therapeutics, Room 3C-385, Houston VA Medical CenterBaylor College of MedicineHoustonUSA
  2. 2.Department of Cell Biology, Molecular Physiology and Biophysics, Medicine and NeurosciencesBaylor College of MedicineHoustonUSA

Bibliographic information

  • Book Title GTPases in Biology I
  • Series Title Handbook of Experimental Pharmacology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-56773-8
  • Softcover ISBN 978-3-642-78269-5
  • eBook ISBN 978-3-642-78267-1
  • Series ISSN 0171-2004
  • Series E-ISSN 1865-0325
  • Edition Number 1
  • Number of Pages XLIII, 697
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Pharmacology/Toxicology
    Biochemistry, general
    Cell Biology
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