Advertisement

Adhesion in Leukocyte Homing and Differentiation

  • Dominique Dunon
  • Charles R. Mackay
  • Beat A. Imhof

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 184)

Table of contents

  1. Front Matter
    Pages I-IX
  2. The Dominance of Antigern-Specific Receptors in Antigen-Specific Immune Responses

  3. Adhesion Molecules

    1. Front Matter
      Pages 5-5
    2. A. Sonnenberg
      Pages 7-35
    3. H. M. DeLisser, P. J. Newman, S. M. Albelda
      Pages 37-45
    4. D. Vestweber
      Pages 65-75
  4. Regulation of Leukocyte-Endothelial Cell Adhesion

  5. Lymphoid Cell Homing Mechanisms

    1. Front Matter
      Pages 107-107
    2. A. Hamann, S. Rebstock
      Pages 109-124
    3. M. C.-T. Hu, B. Holzmann, D. T. Crowe, H. Neuhaus, I. L. Weissman
      Pages 125-138
    4. D. Dunon, P. Ruiz, B. A. Imhof
      Pages 139-150
    5. R. Pabst, R. M. Binns, H. J. Rothkötter, J. Westermann
      Pages 151-159
    6. A. J. Young, J. B. Hay, C. R. Mackay
      Pages 161-173
  6. Leukocyte Homing to Inflamed Tissues

    1. Front Matter
      Pages 175-175
    2. C. W. Smith
      Pages 201-212
  7. Adhesion Molecules in Differentiation and Activation of Lymphocytes

    1. Front Matter
      Pages 213-213
    2. P. W. Kincade, Q. He, K. Ishihara, K. Miyake, J. Lesley, R. Hyman
      Pages 215-222
    3. T. L. Collins, W. C. Hahn, B. E. Bierer, S. J. Burakoff
      Pages 223-233
    4. Y. van Kooyk, C. G. Figdor
      Pages 235-248
  8. Back Matter
    Pages 249-262

About this book

Introduction

This volume of Current Topics in Microbiology and Immunology was planned in parallel with an EM BO workshop on cell-cell Interactions in Leukocyte Homing and Differentiation held at the Basel Institute for Immunology in November 1992, and many of the workshop speakers have contributed to it. Cell adhesion is one of the most dynamic fields of biological research and presented in this book is the current knowledge on the structure and function of the major families of cell adhesion molecules-the integrins, the selectins, the immunoglobulin superfamily, and CD44. Complex interactions between the members of these families mediate diverse adhesion functions, including leukocyte-leukocyte interactions, lymphocyte homing, inflammation, and lymphocyte-stromal cell interaction during hematopoiesis. A great deal of emphasis is placed on the regulatory elements that control the expression and function of adhesion molecules. Cytokines not only induce the expression of certain adhesion molecules, but may also modify their functional status. For instance, the integrins exist in either an inactive nonfunctional form or an active functional form, and a number of intracellular or extracellular stimuli modify integrin function. This is particularly important during leukocyte binding to endothelium and transendothelial migration, which proceeds through a cascade of adhesion events. Although cell adhesion molecules play an important role in many processes, this book concentrates on their role within the immune system. A number of chapters discuss the migration of lymphocytes between hematopoietic organs such as the thymus, lymph nodes, Peyer's patches, and spleen.

Keywords

Filtration Lymphozyten T cell Thymus antigen cell cytokine growth factor immune response immune system immunoglobulin inflammation lymphocytes migration receptor

Editors and affiliations

  • Dominique Dunon
    • 1
  • Charles R. Mackay
    • 1
  • Beat A. Imhof
    • 1
  1. 1.Basel Institute for ImmunologyBaselSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-78253-4
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-78255-8
  • Online ISBN 978-3-642-78253-4
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
Industry Sectors
Pharma
Biotechnology
Consumer Packaged Goods