Basic and Clinical Aspects of Helicobacter pylori Infection

1. Pathogenic Mechanisms of Helicobacter pylori Infection: Virulence

   1. Helicobacter pylori: Phospholipase C and Haemolysis

      • M. A. Daw, H. X. Xia, C. O’Morain

      Pages 85-89

   2. Haemagglutinins of Helicobacter pylori and Adherence to HEp-2 Cells

      • C. S. Goodwin

      Pages 90-91

   3. Partial Purification and Characterization of Sialic Acid Specific Soluble Haemagglutinin(s) of Helicobacter pylori Strain NCTC 11637

      • J. Lelwala-Guruge, A. S. Kreger, W. Shen, T. Wadström

      Pages 92-97

2. Pathogenic Mechanisms of Helicobacter pylori Infection: Host Response

   1. Front Matter

      Pages 99-99

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   2. The Role of Helicobacter pylori Gastritis in Ulcerogenesis and Carcinogenesis

      • E. Solcia, R. Fiocca, L. Villani, O. Luinetti, A. Gianatti, E. Trespi et al.

      Pages 101-112

   3. Isolation and Phenotypical Characterization of T-Lymphocytes Isolated from the Gastric Mucosa of Patients With and Without Helicobacter pylori

      • W. P. Brooks, G. Meimarakis, R. A. Hatz, E. Bayerdörffer, G. Enders, H. J. Krämling

      Pages 113-118

   4. Demonstration of the Major Cytotoxin-Associated Protein of Helicobacter pylori in Gastric Biopsies by Western Blotting

      • N. Figura, M. Bugnoli, S. Quaranta, M. Corsetti, D. Armellini, M. Matergi et al.

      Pages 119-121

   5. Gastric Functions and Helicobacter pylori Infection in Patients with Fundic Atrophic Gastritis

      • R. Corinaldesi, A. Tucci, V. Stanghellini, C. Tosetti, S. Gasperoni, G. F. Paparo et al.

      Pages 122-124

   6. Peptic Ulcer in the Elderly: Not a Helicobacter-Related Condition?

      • J. I. Wyatt, T. M. Shallcross, R. V. Heatley

      Pages 125-127

3. Serology of Helicobacter pylori Infection

   1. Front Matter

      Pages 129-129

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   2. Introduction

      • L. P. Andersen, D. G. Newell

      Pages 131-132

   3. The Use of Helicobacter pylori Serology in Diagnosis and Treatment Monitoring

      • L. P. Andersen

      Pages 133-135

   4. The Use of Serological Detection of Helicobacter pylori in Epidemiology

      • D. Forman

      Pages 136-138

   5. Helicobacter pylori Serology: Kit Evaluation and Comparison

      • E. De Koster, P. Denis, H. Goossens, J. F. Nyst, M. Deltenre

      Pages 139-144

   6. Standards for Serologic Study of Infection with Helicobacter pylori

      • R. Feldman, S. J. W. Evans, J. Deeks, B. Rathbone, The Helicobacter pylori Serology Study Group

      Pages 145-153

   7. Helicobacter pylori Antigenic Preparations

      • A. R. Stacey

      Pages 154-158

   8. The Value of Class and Subclass ELISAs and Antibody Specificity in Monitoring Treatment of Helicobacter pylori

      • A. R. Stacey, G. D. Bell, D. G. Newell

      Pages 159-163

   9. Future Prospects for Helicobacter pylori Serology

      • D. G. Newell

      Pages 164-167

   10. The Helicobacter pylori-San Marino Study: Seroepidemiology of Helicobacter pylori Infection in the Republic of San Marino

       • G. Gasbarrini, S. Pretolani, G. C. Ghironzi, G. Giulianelli, E. Tonelli, M. R. A. Gatto et al.

       Pages 168-176

4. Molecular Biology of Helicobacter pylori

   1. Front Matter

      Pages 177-177

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A century ago the Italian pathologist Bizzozero described the relationships between spiral bacteria and the mammalian gastro­ intestinal tract. Since 1982, when Helicobacter pylori was discovered, gastroduodenal disease have been completely revised as a con­ sequence of the results of basic and clinical research in this field. Progress in understanding the pathogenesis of this bacterium has been made by studying H. pylori infection in animal models. More specific diagnostic tools have been developed using new molecular biology techniques. Future trends are directed towards preparing a specific H. pylori vaccine. A new classification for gastritis, the Sydney System, including H. pylori gastritis, was proposed in 1990. As concerns the clinical approach to peptic ulcer disease in the 1990's, the majority of authors agree on the importance of H. pylori eradication. Moreover, recent clinical studies suggest that H. pylori infection can be associated with other gastroduodenal diseases, such as non ulcer dyspepsia and gastric cancer. Multicenter trials to standardize serological methods and evaluate the efficacy of new antimicrobial therapy schedules are planned throughout different European countries. The fourth Workshop of the European Helicobacter Pylori Study Group was held in Bologna, Italy, in November 1991. Two years before Bologna University celebrated its ninth centennial, giving evidence of being the oldest University in the modern world. Thus the H. pylori story that has continued for more than a century has been discussed once again at the University with the oldest tradition in the world.

• Gastritis
• Gastroduodenal Pathology
• Gastroduodenale Pathologie
• antibiotic
• antibody
• antigen
• biopsy
• endoscopy
• gene
• helicobacter pylori
• infection
• molecular biology
• pathogenesis
• stomach
• surgery

• I. Patologia Medica, Policlinico S. Orsola, Bologna, Italy

  G. Gasbarrini, S. Pretolani

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