The HLA System in Clinical Transplantation

Basic Concepts and Importance

  • Bjarte G. Solheim
  • Soldano Ferrone
  • Erna Möller

Table of contents

  1. Front Matter
    Pages I-XIX
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. J. Klein, C. Schönbach
      Pages 16-37
  3. Genetics, Chemistry and Expression

    1. Front Matter
      Pages 39-39
    2. J. Trowsdale, I. Hanson
      Pages 41-48
    3. J. J. Neefjes, H. L. Ploegh
      Pages 63-81
    4. E. Simpson
      Pages 91-106
  4. Biological Function of MHC Molecules

    1. Front Matter
      Pages 107-107
    2. B. Benacerraf
      Pages 109-118
    3. R. Tisch, L. Fugger, S. M. Singer, H. O. McDevitt
      Pages 148-166
  5. Allorecognition of HLA Molecules

    1. Front Matter
      Pages 199-199
    2. E. Kaminski, A. Martin, B. A. Bradley
      Pages 201-213
    3. J. G. Bodmer, S. G. E. Marsh, J. M. Heyes, L. J. Kennedy, J. H. Moses, A. M. Sadler et al.
      Pages 214-231
    4. E. Möller, S. Sumitran-Karuppan
      Pages 243-257
  6. HLA-Matching

    1. Front Matter
      Pages 259-259
    2. T. Leivestad, E. Vartdal, E. Thorsby
      Pages 261-269
    3. F. H. J. Claas, L. Zhang, J. J. van Rood
      Pages 270-276
    4. P. Fauchald, D. Albrechtsen, A. V. Reisaeter, A. Jakobsen, B. G. Solheim
      Pages 277-283
  7. Immunosuppression

    1. Front Matter
      Pages 285-285
    2. J.-F. Bach, J.-P Viard
      Pages 287-299
    3. S. M. Mariani, E. A. Armandola, S. Ferrone
      Pages 317-324
  8. Rejection

    1. Front Matter
      Pages 325-325
    2. R. Renkonen, I. Lautenschlager, P. Häyry
      Pages 327-338
  9. Bone Marrow Transplantation

    1. Front Matter
      Pages 349-349
    2. G. Kvalheim
      Pages 373-380
  10. Xenografting

    1. Front Matter
      Pages 381-381
    2. J. Buyske, H. Auchincloss Jr.
      Pages 383-391
  11. Malignancy after Transplantation

    1. Front Matter
      Pages 393-393
    2. I. Penn
      Pages 395-404
  12. Addendum

    1. Front Matter
      Pages 405-405
    2. Jan Klein, Ronald E. Bontrop, Roger L. Dawkins, Henry A. Erlich, Ulf B. Gyllensten, Eugene R. Heise et al.
      Pages 407-411
    3. Jan Klein, Christophe Benoist, Chella S. David, Peter Demant, Kirsten Fischer Lindahl, Lorraine Flaherty et al.
      Pages 412-417
  13. Back Matter
    Pages 419-429

About this book


With this book we· want to address young graduate students, clini­ cians involved in transplantation, and technicians in transplantation immunology laboratories. The volume should give a comprehensive but basic, up to date introduction to the structure, function, and clinical importance of the HLA system. We believe that there is a need for such a survey, and think that the present level of our knowledge is an optimal occasion for publication. A significant number of ques­ tions have now been resolved, and our knowledge has reached a level of sophistication that provides the basis for additional questions and answers. Although the emphasis of this book is on the role of HLA anti­ gens in clinical transplantation, their involvement in other clinical contexts is also discussed. The main focus is on the human MHC an­ tigenic system, but MHC systems in other species are described as they contribute to our understanding of the structural and functional characteristics of HLA antigens. Some important issues related to laboratory techniques are also covered. The contributors have a close affiliation to the field of transplan­ tation immunology. A majority have even been playing important roles in unraveling the HLA system and its functions. We believe this has contributed significantly to the quality and clinical and practical relevance of the book. As editors, we drew up the principal guidelines and took care that the chapters can be read as separate entities, although this invariably results in some overlapping.


Antigen Immunologie Knochenmark Knochenmarktransplantation Organtransplantation biopsy cell genetics hematology histocompatibility immunology immunosuppression physiology transplantation tumor

Editors and affiliations

  • Bjarte G. Solheim
    • 1
  • Soldano Ferrone
    • 2
  • Erna Möller
    • 3
  1. 1.Department Group for Laboratory MedicineUniversity of Oslo RikshospitaletOsloNorway
  2. 2.Department of Microbiology and ImmunologyNew York Medical CollegeValhallaUSA
  3. 3.Department for Clinical ImmunologyHuddinge sjukhusHuddingeSweden

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-77508-6
  • Online ISBN 978-3-642-77506-2
  • Buy this book on publisher's site