© 1992

DNA Replication: The Regulatory Mechanisms

  • Patrick Hughes
  • Ellen Fanning
  • Masamichi Kohiyama
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XX
  2. Introduction

  3. Cellular DNA Replication

    1. Cell cycle control of DNA replication

    2. Origin identification in mammalian chromosomes

      1. William C. Burhans, Lyubomir T. Vassilev, Jiarui Wu, José M. Sogo, Ferez S. Nallaseth, Melvin L. DePamphilis
        Pages 73-82
      2. Joel A. Huberman, Dharani D. Dubey, Kevin A. Nawotka, George Russev, J. Aquiles Sanchez, Yeup Yoon et al.
        Pages 83-95
      3. Bonita J. Brewer
        Pages 97-106
    3. Origin structure. function and modification

      1. M. Zannis-Hadjopoulos, C. E. Pearson, D. Bell, D. Mah, M. McAlear, G. B. Price
        Pages 107-116
      2. Stephen E. Kearsey, David Kipling
        Pages 117-127
      3. Zong-Sheng Guo, Maria Wiekowski, Sadhan Majumder, Miriam Miranda, Melvin L. DePamphilis
        Pages 129-138
      4. V. A. Zakian, S.-S. Wang, R. Wellinger
        Pages 139-150
    4. Initiator — replication origin recognition

      1. Christoph Schaefer, Andreas Holz, Walter Messer
        Pages 161-168
      2. James F. Theis, Carol S. Newlon
        Pages 169-179
      3. P. R. Rhode, J. L. Campbell
        Pages 193-204
      4. B. K. Tye, V. Chang, C. Christ, R. Elble, S. Gibson, S. Passmore et al.
        Pages 205-213

About these proceedings


DNA replication is a key event in the cell cycle. Although our knowledge is far from complete and many elusive regulatory mechanisms still remain beyondour grasp, many enzymes and a multiplicity of biochemical mechanisms involved have been discovered. Recent findings in E. coli have confirmed and yet surpassed the original hypothesis of F. Jacob. In yeast and higher eucaryotes, the apparent redundancy in putative origins and initiators has made an estimation of the importance of each identified element difficult to access. In spite of well established methodologies - which are also described in the book - the origin identification in mammalian chromosomes is still a controversial subject. On the other hand, considerable advances have been made in our understanding of virus DNA replication and this continues to deepen and broaden our understanding of the controls of cellular DNA replication.


ATP DNA cell cell cycle cell division cell membrane chromosome enzyme enzymes mutation protein proteins replication synthesis transcription

Editors and affiliations

  • Patrick Hughes
    • 1
  • Ellen Fanning
    • 2
  • Masamichi Kohiyama
    • 1
  1. 1.Institut Jacques Monod, CNRSUniversité Paris 7Paris Cedex 05France
  2. 2.Institut für BiochemieMünchen 2Germany

Bibliographic information

  • Book Title DNA Replication: The Regulatory Mechanisms
  • Editors Patrick Hughes
    Ellen Fanning
    Masamichi Kohiyama
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1992
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-54633-7
  • Softcover ISBN 978-3-642-76990-0
  • eBook ISBN 978-3-642-76988-7
  • Edition Number 1
  • Number of Pages XX, 422
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Cell Biology
    Biochemistry, general
  • Buy this book on publisher's site
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