DNA Replication: The Regulatory Mechanisms

  • Patrick Hughes
  • Ellen Fanning
  • Masamichi Kohiyama
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XX
  2. Introduction

  3. Cellular DNA Replication

    1. Cell cycle control of DNA replication

    2. Origin identification in mammalian chromosomes

      1. William C. Burhans, Lyubomir T. Vassilev, Jiarui Wu, José M. Sogo, Ferez S. Nallaseth, Melvin L. DePamphilis
        Pages 73-82
      2. Joel A. Huberman, Dharani D. Dubey, Kevin A. Nawotka, George Russev, J. Aquiles Sanchez, Yeup Yoon et al.
        Pages 83-95
      3. Bonita J. Brewer
        Pages 97-106
    3. Origin structure. function and modification

      1. M. Zannis-Hadjopoulos, C. E. Pearson, D. Bell, D. Mah, M. McAlear, G. B. Price
        Pages 107-116
      2. Stephen E. Kearsey, David Kipling
        Pages 117-127
      3. Zong-Sheng Guo, Maria Wiekowski, Sadhan Majumder, Miriam Miranda, Melvin L. DePamphilis
        Pages 129-138
      4. V. A. Zakian, S.-S. Wang, R. Wellinger
        Pages 139-150
    4. Initiator — replication origin recognition

      1. Christoph Schaefer, Andreas Holz, Walter Messer
        Pages 161-168
      2. James F. Theis, Carol S. Newlon
        Pages 169-179
      3. P. R. Rhode, J. L. Campbell
        Pages 193-204
      4. B. K. Tye, V. Chang, C. Christ, R. Elble, S. Gibson, S. Passmore et al.
        Pages 205-213
      5. John F. X. Diffley, Bruce Stillman
        Pages 215-223
    5. Initiator interactions with DNA polymerases and accessory proteins

      1. Rafael Giraldo, Margarita Martín, María Elena Femández-Tresguerres, Concepción Nieto, Ramón Díaz
        Pages 225-237
      2. R. Knippers, Ch. Lambrecht, H. Romig, A. Richter, N. Kunze
        Pages 239-250
      3. Peter M. J. Burgers
        Pages 251-260
      4. G. Baldacci, D. Bouvier, V. Damagnez, G. Pignède, A-M. de Recondo
        Pages 261-271
      5. G. Faye, F. Fabre, M. Simon, L. Giot, A. Boulet, P. Bénit et al.
        Pages 273-284
      6. P. Plevani, M. Foiani, S. Francesconi, A. Pizzagalli, C. Santocanale, M. Falconi Muzi et al.
        Pages 285-294
  4. Viral and Plasmid DNA Replication

    1. Molecular interactions during protein primed initiation

      1. M. Salas, M. Serrano, C. Gutiérrez, J. A. Esteban, M. A. Blasco, A. Bernad et al.
        Pages 295-306
      2. R. T. Hay, J. Bosher, A. Dawson, S. M. Temperley
        Pages 307-319
      3. Jeffrey A. Engler, Insil Joung, Jeffrey N. Fredman, Steven C. Pettit, Carl Abraham, Marshall S. Horwitz
        Pages 321-330
      4. P. C. van der Vliet, C. P. Verrijzer, Y. M. Mul, J. A. W. M. van Oosterhout, W. van Driel
        Pages 331-346
    2. Molecular interactions at origins on circular viral and phage DNA

      1. K. Liberek, D. Skowyra, J. Marszalek, J. Osipiuk, M. Zylicz, D. Ang et al.
        Pages 359-368
      2. Kathleen L. Collins, Lome F. Erdile, Sandra K. Randall, Alicia A. R. Russo, Pamela R. Simancek, Christopher B. Umbricht et al.
        Pages 369-384
      3. Christine Schneider, Dorothea von Winkler, Irene Dornreiter, Heinz-Peter Nasheuer, Ilka Gilbert, Silke Dehde et al.
        Pages 385-397
      4. Sabine Santucci, Catherine Bonne-Andréa, Philippe Clertant
        Pages 399-416
  5. Back Matter
    Pages 417-422

About these proceedings


DNA replication is a key event in the cell cycle. Although our knowledge is far from complete and many elusive regulatory mechanisms still remain beyondour grasp, many enzymes and a multiplicity of biochemical mechanisms involved have been discovered. Recent findings in E. coli have confirmed and yet surpassed the original hypothesis of F. Jacob. In yeast and higher eucaryotes, the apparent redundancy in putative origins and initiators has made an estimation of the importance of each identified element difficult to access. In spite of well established methodologies - which are also described in the book - the origin identification in mammalian chromosomes is still a controversial subject. On the other hand, considerable advances have been made in our understanding of virus DNA replication and this continues to deepen and broaden our understanding of the controls of cellular DNA replication.


ATP DNA cell cell cycle cell division cell membrane chromosome enzyme enzymes mutation protein proteins replication synthesis transcription

Editors and affiliations

  • Patrick Hughes
    • 1
  • Ellen Fanning
    • 2
  • Masamichi Kohiyama
    • 1
  1. 1.Institut Jacques Monod, CNRSUniversité Paris 7Paris Cedex 05France
  2. 2.Institut für BiochemieMünchen 2Germany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1992
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-76990-0
  • Online ISBN 978-3-642-76988-7
  • Buy this book on publisher's site
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