Physiology and Pharmacology of the Blood-Brain Barrier

  • Michael W. B. Bradbury

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 103)

Table of contents

  1. Front Matter
    Pages I-XXIII
  2. M. W. Brightman
    Pages 1-22
  3. Q. R. Smith
    Pages 23-52
  4. A. Gjedde
    Pages 65-115
  5. J.-M. Lefauconnier
    Pages 117-150
  6. D. J. Begley
    Pages 151-203
  7. O. E. Pratt
    Pages 205-220
  8. G. P. Schielke, A. L. Betz
    Pages 221-243
  9. H. F. Cserr, C. S. Patlak
    Pages 245-261
  10. M. W. B. Bradbury
    Pages 263-278
  11. P. J. Robinson, S. I. Rapoport
    Pages 279-300
  12. J. J. Laterra, G. W. Goldstein
    Pages 417-437
  13. P. J. Luthert
    Pages 439-457
  14. M. K. Gumerlock, E. A. Neuwelt
    Pages 525-542
  15. Back Matter
    Pages 543-552

About this book


The blood-brain barrier is still not completely understood and therefore the subject of fascinating study. How are endogenous substances transported through the blood-brain barrier? What are the known therapeutic and toxic agents? How are they transported across cerebral microvessels? The discussion of these and other questions with far-reaching consequences for all neuroscientists can be found in this volume. This authoritative and up-to-date review of the blood-brain barrier gives a proper understanding of the topic. The experimental principles, the results of very recent research, as well as the implications that experimental research has for clinical treatment are thoroughly covered. Information is given on: - new findings based on classical physiological and pharmacological techniques, - results obtained from brain capillaries in vitro and in culture, - results obtained from the new scanning techniques (PET and MRI), - the immunology of the blood-brain barrier, - trace metal transport, - the pathological breakdown of the barrier and - the modification of drugs to increase their entry into the brain. Here is a source of information that is invaluable to specialists concerned with basic research in the neurosciences, with the design of neuropharmacological agents, with the radiological diagnosis of cerebral pathology or with the treatment of cerebral lesions!


Amino acid Blood-Brain Barrier Blut-Hirn-Schranke Cerebral Capillaries Cerebral Endothelium Hirnkreislauf Permeability of Blood-Brain Barrier diagnosis neuroscience physiology positron emission tomography

Editors and affiliations

  • Michael W. B. Bradbury
    • 1
  1. 1.Physiology Group Biomedical Sciences Division King’s College LondonUniversity of LondonLondonGreat Britain

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1992
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-76896-5
  • Online ISBN 978-3-642-76894-1
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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