Comparative Aspects of Mechanoreceptor Systems

  • Fumio Ito

Part of the Advances in Comparative and Environmental Physiology book series (COMPARATIVE, volume 10)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Mechanosensitive Ion Channels

    1. Front Matter
      Pages 1-1
    2. B. Martinac, A. H. Delcour, M. Buechner, J. Adler, C. Kung
      Pages 3-18
  3. Mechanoreceptor Organs

    1. Front Matter
      Pages 79-79
    2. B. G. Pickard, J. Ping Ding
      Pages 81-110
    3. J. G. Widdicombe, G. Sant’Ambrogio
      Pages 111-135
    4. M. W. Chapleau
      Pages 137-164
    5. H. Römer, J. Tautz
      Pages 185-212
    6. B. Rydqvist
      Pages 233-260
    7. F. Ito, M. Sokabe, N. Fujitsuka
      Pages 261-280
    8. M. H. Gladden
      Pages 281-302
  4. Back Matter
    Pages 303-309

About this book


In the past 5 years there has been an enormous increase of evidence that the ion channels activated by mechanical force are common to a wide variety of cell types. Mechanosensitive (MS) ion channels form a small proportion of the total channel population. They are now found in more than 30 cell types from E. coli, yeast, to plant, invertebrate, and vertebrate cells, where they occur in virtually all types of cells from bone to smooth muscle, as well as neurons. The majority of MS channels are permeable to monovalent cations and are slightly selective for K+ over Na +. How­ 2 ever, there are several reports of anion-selective MS channels, MS Ca + channels, and MS channels with large conductances that do not dis­ criminate markedly between cations and anions. Recently B. Hille has postulated possible evolutionary relationships between several types of ion channels, with mechanosensitive channels predating even the eukaryotes. Two voltage-gated channel types originate with the stem eukaryotes, as deduced from the presence of voltage-gated K+ 2 and Ca + channels in protozoa, algae, or higher plants. Agonist-gated chan­ nels as well as voltage-gated Na + channels appear with the earliest metazoan animals, as deduced from the presence of Na + spikes and fast chemical synapses in cnidaria (coelenterates), ctenophores, and all higher animals.


Ionenkanal Protozoa Reizleitung Synapse bone cells eukaryota eukaryote ion channels mechanoreceptor neurons physiology receptor signal transduction smooth muscle

Editors and affiliations

  • Fumio Ito
    • 1
  1. 1.Department of Physiology School of MedicineNagoya UniversityShowa-ku, NagoyaJapan

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1992
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-76692-3
  • Online ISBN 978-3-642-76690-9
  • Series Print ISSN 0938-2763
  • Buy this book on publisher's site
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