© 1991

Novel Calcium-Binding Proteins

Fundamentals and Clinical Implications

  • Claus W. Heizmann

Table of contents

  1. Front Matter
    Pages I-5
  2. Preface

    1. Claus W. Heizmann
      Pages 13-13
  3. Calcium Signaling by Calcium-Binding Proteins

    1. Front Matter
      Pages 15-15
    2. Robert H. Kretsinger, David Tolbert, Susumu Nakayama, William Pearson
      Pages 17-37
    3. Yogendra Sharma, Doraivajan Balasubramanian
      Pages 51-61
  4. EF-Hand Calcium-Binding Proteins: the S-100 Protein Family

  5. Novel Members of the EF-Hand Calcium-Binding Protein Family in Normal and Transformed Cells

    1. Front Matter
      Pages 249-249
    2. John H. Rogers
      Pages 251-276

About this book


A wide variety of hormones, neurotransmitters and growth factors exert their cellular effects by reacting first with membrane receptors resulting in an increase of intracellular calcium and the cellular response. The calcium signal in the cell is mediated by the high-affinity calcium binding proteins (characterized by the EF-hand structural element), and by the calcium and phospholipid dependent proteins. Many of these have been discovered most recently. Their purification, distribution, protein and gene structures as well as their physiological roles are discussed. The book is of interest to biochemists and molecular biologists as well as to clinicians and the pharmaceutical industry who can apply the results in this field.


Calcium Calcium bindende Proteine Calcium-binding proteins Kalzium cell gene hormones lipide membrane neurotransmitter protein proteins receptor

Editors and affiliations

  • Claus W. Heizmann
    • 1
  1. 1.Department of Pediatrics Division of Clinical ChemistryUniversity of ZürichZürichSwitzerland

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