Novel Calcium-Binding Proteins

Fundamentals and Clinical Implications

  • Claus W. Heizmann

Table of contents

  1. Front Matter
    Pages I-5
  2. Preface

    1. Claus W. Heizmann
      Pages 13-13
  3. Calcium Signaling by Calcium-Binding Proteins

    1. Front Matter
      Pages 15-15
    2. Robert H. Kretsinger, David Tolbert, Susumu Nakayama, William Pearson
      Pages 17-37
    3. Yogendra Sharma, Doraivajan Balasubramanian
      Pages 51-61
  4. EF-Hand Calcium-Binding Proteins: the S-100 Protein Family

  5. Novel Members of the EF-Hand Calcium-Binding Protein Family in Normal and Transformed Cells

    1. Front Matter
      Pages 249-249
    2. John H. Rogers
      Pages 251-276
    3. J. Jongstra, J. Jongstra-Bilen, S. Galea, D. P. Klein
      Pages 301-320
    4. Walter Witke, Angelika A. Noegel, Michael Schleicher
      Pages 321-337
    5. Doraivajan Balasubramanian, Yogendra Sharma
      Pages 361-374
    6. Anne Lefort, Raymond Lecocq, Frédérick Libert, Christophe Erneux, Françoise Lamy, Jacques Dumont
      Pages 375-384
  6. Calcium-Binding Proteins in Bacteria, Fungi, and Invertebrates. Structure, Function, and Evolution

    1. Front Matter
      Pages 401-401
    2. Karla S. Booth, Winslow S. Caughey, Shioko Kimura, Masao Ikeda-Saito
      Pages 425-435
    3. Martin Teintze, Masayori Inouye, Sumiko Inouye
      Pages 437-446
    4. Jos A. Cox, Ying Luan-Rilliet, Takashi Takagi
      Pages 447-463
    5. William H. Klein, Mengqing Xiang, Gary M. Wessel
      Pages 465-479
    6. Tohru Takemasa, Takashi Takagi, Yoshio Watanabe
      Pages 481-495
    7. Olaf Pongs, Imke Krah-Jentgens, Dieter Engelkamp, Alberto Ferras
      Pages 497-503
    8. Rita Reifegerste, Claudia Faust, Norbert Lipski, Gertrud Heimbeck, Alois Hofbauer, Gert Pflugfelder et al.
      Pages 505-510
  7. Calcium Fluxes, Binding, and Metabolism

    1. Front Matter
      Pages 511-511
    2. Paul Erne, Maryse Crabos, Dieter Engelkamp, Fritz R. Bühler, Claus W. Heizmann
      Pages 523-532
  8. Calcium-Dependent and Phospholipid-Binding Proteins in Health and Disease

    1. Front Matter
      Pages 533-533
    2. Stephen E. Moss, Helena C. Edwards, Michael J. Crumpton
      Pages 535-566
    3. Eisuke F. Sato, Yoshikazu Tanaka, Keisuke Edashige, Junzo Sasaki, Masayasu Inoue, Kozo Utsumi
      Pages 567-587
  9. Back Matter
    Pages 613-624

About this book


A wide variety of hormones, neurotransmitters and growth factors exert their cellular effects by reacting first with membrane receptors resulting in an increase of intracellular calcium and the cellular response. The calcium signal in the cell is mediated by the high-affinity calcium binding proteins (characterized by the EF-hand structural element), and by the calcium and phospholipid dependent proteins. Many of these have been discovered most recently. Their purification, distribution, protein and gene structures as well as their physiological roles are discussed. The book is of interest to biochemists and molecular biologists as well as to clinicians and the pharmaceutical industry who can apply the results in this field.


Calcium Calcium bindende Proteine Calcium-binding proteins Kalzium cell gene hormones lipide membrane neurotransmitter protein proteins receptor

Editors and affiliations

  • Claus W. Heizmann
    • 1
  1. 1.Department of Pediatrics Division of Clinical ChemistryUniversity of ZürichZürichSwitzerland

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-76152-2
  • Online ISBN 978-3-642-76150-8
  • Buy this book on publisher's site
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