Mechanisms in B-Cell Neoplasia 1990

1. Experimental Plasmacytomas and B-Cell Tumors

   1. Identification of Consensus Genes Expressed in Plasmacytomas but Not B Lymphomas

      • C. Timblin, P. L. Bergsagel, W. M. Kuehl

      Pages 141-147

   2. Proliferation of B Cell Precursors in Bone Marrow of Pristane-Conditioned and Malaria-Infected Mice: Implications for B Cell Oncogenesis

      • D. G. Osmond, S. Priddle, S. Rico-Vargas

      Pages 149-157

   3. The Human CBL Oncogene

      • W. Y. Langdon, T. J. Blake

      Pages 159-164

   4. Lymphoid Tumorigenesis by v-abl and BCR-v-abl in Transgenic Mice

      • A. W. Harris, M. L. Bath, H. Rosenbaum, J. McNeall, J. M. Adams, S. Cory

      Pages 165-173

   5. Abnormalities of the Immune System Induced by Dysregulated bcl-2 Expression in Transgenic Mice

      • A. Strasser, A. W. Harris, D. L. Vaux, E. Webb, M. L. Bath, J. M. Adams et al.

      Pages 175-181

2. Growth Regulation to B-Cells: Immortalization

   1. Front Matter

      Pages 183-183

      PDF

   2. Immortalization of Primary Murine B Lymphocytes with Oncogene-Containing Retroviral Vectors

      • R. W. Overell, K. E. Weisser, B. Hess, R. Goodwin, L. Clark, K. H. Grabstein

      Pages 185-188

   3. Functionality of Clonal Lymphoid Progenitor Cells Expressing the P210 BCR/ABL Oncogene

      • P. A. Scherle, O. N. Witte

      Pages 189-195

   4. Constitutive and Cell Cycle Regulated Expression of c-myc mRNA is Related to the State of Differentiation in Murine B-Lymphoid Tumors

      • K. M. Catron, C. R. Toth, J. Purkerson, P. Isakson, T. P. Bender

      Pages 197-202

   5. Bcl-2: B Cell Life, Death and Neoplasia

      • Stanley J. Korsmeyer, Timothy J. McDonnell, Gabriel Nunez, David Hockenbery, Robert Young

      Pages 203-207

3. C-myc Genes in B- Cell Neoplasia

   1. Front Matter

      Pages 209-209

      PDF

   2. Binding of NF-KB-like Factors to Regulatory Sequences of the c-myc Gene

      • M. P. Duyao, D. J. Kessler, D. B. Spicer, G. E. Sonenshein

      Pages 211-220

   3. Tumorigenesis in Transgenic Mice Expressing the c-myc Oncogene with Various Lymphoid Enhancer Elements

      • Richard H. Scheuermann, Steven R. Bauer

      Pages 221-231

   4. Isolation of Normal and Tumor-Specific Pvt-1 cDNA Clones

      • K. Huppi, D. Siwarski, R. M. Skurla Jr., J. Goodnight, J. F. Mushinski

      Pages 233-241

   5. Expression of c-myc and Pvt1

      • J. F. Mushinski, R. M. Skurla Jr., J. Goodnight, D. Siwarski, K. Huppi

      Pages 243-249

   6. Mutational Analysis of the Carboxy-Terminal Casein Kinase II Phosphorylation Site in Human c-myc

      • Alasdair J. Street, Elizabeth Blackwood, Bernhard Lüscher, Robert N. Eisenman

      Pages 251-258

   7. The Transforming Activity of PP59C-MYCis Weaker Than That of v-myc

      • E. H. Humphries, E. J. Filardo

      Pages 259-265

   8. Recombination of the c-myc Gene with IgH Enhancer-Sμ Sequences in a Murine Plasmacytoma (DCPC 21) Without Visible Chromosomal Translocations

      • S. Ohno, S. Migita, S. Murakami

      Pages 267-278

   9. Downstream Regulatory Elements in the c-myc Gene

      • M. Zajac-Kaye, B. Yu, N. Ben-Baruch

      Pages 279-284

   10. DNA Repair in the c-myc Locus

       • E. J. Beecham, J. F. Mushinski, E. Shacter, M. Potter, V. A. Bohr

       Pages 285-291

The eighth workshop in this series on Mechanisms in B-Cell Neoplasia 1990 was held in Wilson Hall at the National Institutes of Health, Bethesda, Maryland on March 28-30. Five major topics formed the basis for the discussions: 1) progress in experimental models of B-cell tumorigenesis, 2) the role of IL-6 in plasma cell tumor formation with particular emphasis on human myeloma, 3) immortaliza­ tion and regulation of mitosis in B-cells, 4) the mYQ gene in B-cell neoplasia, and 5) the role of EBV and other oncogenes in transforma­ tion of human B-Iymphocytes. A meeting on the Epidemiology of Myeloma was held at the N. I. H. on the preceding day, and many of those interested in the clinical aspects of myeloma were also participants at the workshop. Experimental Models of B-Cell Tumor Development We have seen in the last eight years the steady growth of model experimental systems, many of which have been designed to be counter­ parts of the major forms of human B cell tumors, e. g. , follicular lymphomas, Burkitt's lymphomas, acute B-cell leukemia and multiple myeloma. A variety of novel ways of inducing these tumors has been described. Advantage has been taken of the "experiments in nature" to identify critical genes that playa role in tumor pathogenesis. These genes have been identified by being near to viral insertion and chromosomal translocation sites, or by having been incorporated or transduced into a defective transforming retrovirus.

• Burkitt's Lymphoma
• Lymphome
• Myelome
• Neoplasie
• Onkologie
• Tumoren
• oncology
• plasma cells
• tumorigenesis
• tumors

• Laboratory of Genetics, National Institutes of Health, National Cancer Institute, Bethesda, USA

  Michael Potter

• Basel Institute for Immunology, Basel, Switzerland

  Fritz Melchers

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