© 1990

Mechanisms in B-Cell Neoplasia 1990

Workshop at the National Cancer Institute National Institutes of Health Bethesda, MD, USA, March 28–30,1990

  • Michael Potter
  • Fritz Melchers

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 166)

Table of contents

  1. Front Matter
    Pages I-XIX
  2. IL-6 in Multiple Myeloma

    1. Front Matter
      Pages 1-1
    2. K. Nilsson, H. Jernberg, M. Pettersson
      Pages 3-12
    3. S. Suematsu, M. Hibi, T. Sugita, M. Saito, M. Murakami, T. Matsusaka et al.
      Pages 13-22
    4. Brian G. M. Durie, Elizabeth E. Vela, Yvette Frutiger
      Pages 33-36
    5. D. Emilie, M. Peuchmaur, P. Galanaud
      Pages 47-49
  3. Experimental Plasmacytomas and B-Cell Tumors

    1. Front Matter
      Pages 75-75
    2. Richard G. Hoover, Sheryl Roman, Jonni S. Moore, Christine Darby, Susan Müller
      Pages 77-85
    3. David Largaespada, Donal Kaehler, Evi Weissinger, Harold Mischak, Fred Mushinski, Rex Risser
      Pages 91-96
    4. S. Silva, H. Sugiyama, M. Babonits, F. Wiener, G. Klein
      Pages 97-105
    5. F. Wiener, S. Silva, H. Sugiyama, M. Babonits, H. Axelson, P. Chinmay et al.
      Pages 107-119
    6. E. M. Weissinger, D. Largaespada, S. J. Smith-Gill, R. Risser, J. F. Mushinski, H. Mischak
      Pages 121-127
    7. U. R. Rapp, J. Troppmair, M. Carroll, S. May
      Pages 129-139

About this book


The eighth workshop in this series on Mechanisms in B-Cell Neoplasia 1990 was held in Wilson Hall at the National Institutes of Health, Bethesda, Maryland on March 28-30. Five major topics formed the basis for the discussions: 1) progress in experimental models of B-cell tumorigenesis, 2) the role of IL-6 in plasma cell tumor formation with particular emphasis on human myeloma, 3) immortaliza­ tion and regulation of mitosis in B-cells, 4) the mYQ gene in B-cell neoplasia, and 5) the role of EBV and other oncogenes in transforma­ tion of human B-Iymphocytes. A meeting on the Epidemiology of Myeloma was held at the N. I. H. on the preceding day, and many of those interested in the clinical aspects of myeloma were also participants at the workshop. Experimental Models of B-Cell Tumor Development We have seen in the last eight years the steady growth of model experimental systems, many of which have been designed to be counter­ parts of the major forms of human B cell tumors, e. g. , follicular lymphomas, Burkitt's lymphomas, acute B-cell leukemia and multiple myeloma. A variety of novel ways of inducing these tumors has been described. Advantage has been taken of the "experiments in nature" to identify critical genes that playa role in tumor pathogenesis. These genes have been identified by being near to viral insertion and chromosomal translocation sites, or by having been incorporated or transduced into a defective transforming retrovirus.


Burkitt's Lymphoma Lymphome Myelome Neoplasie Onkologie Tumoren oncology plasma cells tumorigenesis tumors

Editors and affiliations

  • Michael Potter
    • 1
  • Fritz Melchers
    • 2
  1. 1.Laboratory of Genetics, National Institutes of HealthNational Cancer InstituteBethesdaUSA
  2. 2.Basel Institute for ImmunologyBaselSwitzerland

Bibliographic information

  • Book Title Mechanisms in B-Cell Neoplasia 1990
  • Book Subtitle Workshop at the National Cancer Institute National Institutes of Health Bethesda, MD, USA, March 28–30,1990
  • Editors Michael Potter
    Fritz Melchers
  • Series Title Current Topics in Microbiology and Immunology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1990
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-52886-9
  • Softcover ISBN 978-3-642-75891-1
  • eBook ISBN 978-3-642-75889-8
  • Series ISSN 0070-217X
  • Edition Number 1
  • Number of Pages XIX, 380
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Allergology
    Medical Microbiology
  • Buy this book on publisher's site