Histamine and Histamine Antagonists

  • Börje Uvnäs

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 97)

Table of contents

  1. Front Matter
    Pages I-XXVI
  2. Current Techniques of Histamine Determination

    1. P. F. Mannaioni
      Pages 3-8
    2. W. Lorenz, E. Neugebauer
      Pages 9-30
    3. M. Ennis
      Pages 31-38
    4. P. T. McBride, M. A. Kaliner
      Pages 67-75
    5. J. P. Green, G. D. Prell
      Pages 77-79
    6. W. Lorenz, E. Neugebauer, B. Uvnäs, M. A. Beaven, M. Ennis, G. Granerus et al.
      Pages 81-92
  3. Heterogeneity of Mast Cells

    1. K. E. Barrett, F. L. Pearce
      Pages 93-117
  4. Control of the Exocytotic Mechanism in Rat Mast Cells

  5. Formation of Histamine: Histidine Decarboxylase

    1. T. Watanabe, Y. Taguchi, K. Maeyama, H. Wada
      Pages 145-163
  6. Catabolism of Histamine

    1. C. Maslinski, W. A. Fogel
      Pages 165-189
  7. Histamine Receptors in Brain

    1. J.-C. Schwartz, J.-M. Arrang, M.-L. Bouthenet, M. Garbarg, H. Pollard, M. Ruat
      Pages 191-242
  8. Structure and Functions of the Histaminergic Neurone System

    1. A. Yamatodani, N. Inagaki, P. Panula, N. Itowi, T. Watanabe, H. Wada
      Pages 243-283
  9. Histamine H2 Receptors and Lung Function

    1. J. C. Foreman
      Pages 285-304
  10. Histamine and the Parietal Cell

    1. K. J. Öbrink
      Pages 305-324
  11. Do Histamine-Storing Cells in the Gastric Mucosa Mediate the Acid-Stimulating Action of Gastrin?

  12. Histamine in Cardiovascular Function and Dysfunction: Recent Developments

    1. R. Levi, L. E. Rubin, S. S. Gross
      Pages 347-383
  13. Histamine in Anaesthesia and Surgery: Causality Analysis

    1. W. Lorenz, W. Dietz, M. Ennis, B. Stinner, A. Doenicke
      Pages 385-439
  14. Histamine in Duodenal Ulcer, Stress-Induced Lesions, and Upper Gastrointestinal Bleeding: Causality Analysis

  15. Histamine and the Blood

    1. K. Tasaka
      Pages 473-510
  16. Histamine in Food

    1. S. A. Slorach
      Pages 511-520
  17. Role of Histamine in the Actions of Neuropeptides and Local Hormones

  18. Antagonists of H1 Receptors of Histamine: Recent Developments

  19. Structural Requirements for Histamine H2 Agonists and H2 Antagonists

    1. H. van der Goot, A. Bast, H. Timmerman
      Pages 573-748
  20. Back Matter
    Pages 749-766

About this book


Together with the two previous volumes of the Handbook of Experimental Pharmacology on histamine and antihistamines the present publication yields a picture of a still rapidly developing field of research. New techniques and new experimental approaches have brought us new knowledge and deeper insight into the biomedical significance of histamine, even if many questions remain to be answered about the functional and medical implications of this old biogenic amine. The present volume covers the progress in histamine research during the past two decades. A significant chapter concerns techniques for histamine determination. As the result of a consensus meeting in Munich in December 1988, a panel of eminent specialists arrived at common recommendations as to the usefulness of the available histamine assays for the most common experimental biomedical conditions. The heterogeneity of mast cells, with great differences in their reactivity to various stimuli, has become apparent, not only among species but also among the tissues of a species. New informa­ tion is presented about the mechanism of exocytosis. The old questions about the role of histamine in the mechanism of gastric secretion and in cardio­ vascular and respiratory functions have been studied with new techniques, and the role of HI and H2 receptors discussed. New observations have been made on the occurrence and possible functions of histaminergic neurons and histamine receptors in CNS where a new type of receptor, the H , seems to 3 be widely represented.


Allergie Antagonist Histamine Mastzelle research

Editors and affiliations

  • Börje Uvnäs
    • 1
  1. 1.Department of PharmacologyKarolinska InstitutetStockholmSweden

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-75842-3
  • Online ISBN 978-3-642-75840-9
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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