Advertisement

Immunological Memory

  • David Gray
  • Jonathan Sprent

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 159)

Table of contents

  1. Front Matter
    Pages I-XI
  2. N. R. Klinman, P.-J. Linton
    Pages 19-35
  3. I. C. M. MacLennan, Y. J. Liu, S. Oldfield, J. Zhang, P. J. L. Lane
    Pages 37-63
  4. R. M. Zinkernagel
    Pages 65-77
  5. H. R. MacDonald, R. C. Budd, J.-C. Cerottini
    Pages 97-109
  6. P. C. L. Beverley
    Pages 111-122
  7. S. Adelstein, H. Pritchard-Briscoe, R. H. Loblay, A. Basten
    Pages 123-138
  8. Back Matter
    Pages 139-144

About these proceedings

Introduction

Although immunologists know rather a lot about the manif­ estation of immunological memory, an understanding of the mechanism of memory at cellular and biochemical levels eludes us. Indeed, as we shall see, it is not even clear which of the several models used to explain the working of memory approximates to the truth. It is in order to report on approaches to this problem and on recent experimental advances in the field of memory cells that this volume has been put together. In the past 4-5 years cell surface molecules that may enable us to define memory Band T cells have been identified. It may now be possible to ask how memory cells are generated and to define what signals are required during or after antigenic encounter for a cell to enter the memory cell pool rather than to terminally differentiate into an effector cell. The transition from virgin cell to memory cell is clearly accompanied by several biochemical changes. For B cells, isotype switching and somatic mutations (leading to affinity maturation) are well-defined phenomena, although the molecular mechanisms remain mys­ terious. Both have received attention in many excellent reviews of late and so are not considered in detail in this book. Neither switching nor somatic mutation is a feature of peripheral T-cell maturation; biochemical differences between virgin and mem­ ory T cells may only relate to differing activation requirements and possibly changes in the expression of accessory molecules.

Keywords

Antigen Immunologisches Gedächtnis Memory-B-Zellen Memory-T-Zellen T-Zell-Merkmale

Editors and affiliations

  • David Gray
    • 1
  • Jonathan Sprent
    • 2
  1. 1.Basel Institute for ImmunologyBaselSwitzerland
  2. 2.Dept. of immunology-IMM4AResearch Inst. of Scripps ClinicLa JollaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-75244-5
  • Copyright Information Springer-Verlag Berlin Heidelberg 1990
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-75246-9
  • Online ISBN 978-3-642-75244-5
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
Industry Sectors
Pharma
Health & Hospitals
Biotechnology
Consumer Packaged Goods