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Cytomegaloviruses

  • James K. McDougall

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 154)

Table of contents

  1. Front Matter
    Pages I-IX
  2. Gene Expression

    1. Front Matter
      Pages 1-1
    2. T. Stamminger, B. Fleckenstein
      Pages 3-19
    3. D. H. Spector, K. M. Klucher, D. K. Rabert, D. A. Wright
      Pages 21-45
    4. E. S. Mocarski Jr., G. B. Abenes, W. C. Manning, L. C. Sambucetti, J. M. Cherrington
      Pages 47-74
    5. J. A. Nelson, J. W. Gnann Jr., P. Ghazal
      Pages 75-100
    6. H. C. Isom, C. Y. Yin
      Pages 101-121
  3. Protein Coding

    1. Front Matter
      Pages 123-123
    2. M. S. Chee, A. T. Bankier, S. Beck, R. Bohni, C. M. Brown, R. Cerny et al.
      Pages 125-169
  4. Immune Response

    1. Front Matter
      Pages 187-187
    2. U. H. Koszinowski, M. Del Val, M. J. Reddehase
      Pages 189-220
  5. Back Matter
    Pages 275-279

About these proceedings

Introduction

Named for the enlarged, inclusion-bearing cells characteristic of infection by these viruses, cytomegaloviruses present a significant challenge to both microbiologist and immunologist. Although most primary infections in humans are subclinical, cytomegalovirus can be associated with a wide spectrum of disease, particularly when infection occurs in the immuno­ compromised individual or as a result of congenital or perinatal infection. Although reinfection with cytomegalovirus has been demonstrated, most recurrent and persistent infections result from the reactivation of latent virus. Cytomegaloviruses, like other members of the Herpesviridae family, have the capacity to establish latency after a primary infection but the mechanisms for establishing the nonreplicating but reactivat­ able state have not been defined. The factors responsible for the spectrum of manifestations of cytomegalovirus infection are largely undetermined but host immunological function, route of infection, and size of inoculum all contribute to the extent and severity of disease. Cytomegaloviruses have the largest genomes in the herpes­ virus family, approximately 240 kilo base pairs, providing a potential coding capacity for more than 200 proteins of which less than one-fourth have been mapped and described. There are many similarities to other herpes viruses in genome structure and gene expression; for example, three temporal classes of genes can be identified as rx (immediate-early), f3 (early), and y (late) products. The first five chapters of this volume review and describe recent developments in understanding the trans­ cription and regulation of these gene classes.

Keywords

AIDS Herpes-Virus Immunschwäche Mononukleose Organtransplantationen

Editors and affiliations

  • James K. McDougall
    • 1
  1. 1.Fred Hutchinson Cancer Research CenterUniversity of WashingtonSeattleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-74980-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 1990
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-74982-7
  • Online ISBN 978-3-642-74980-3
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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