• Pedro Cuatrecasas
  • Steven Jacobs

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 92)

Table of contents

  1. Front Matter
    Pages I-XVIII
  2. Insulin

    1. Front Matter
      Pages 1-1
    2. D. Brandenburg
      Pages 3-22
    3. U. Derewenda, Z. S. Derewenda, G. G. Dodson, R. E. Hubbard
      Pages 23-39
  3. Biosynthesis, Secretion, and Degradation

    1. Front Matter
      Pages 65-65
    2. D. F. Steiner
      Pages 67-92
    3. M. D. Walker
      Pages 93-111
    4. R. J. Rushakoff, R. A. Liddle, J. A. Williams, I. D. Goldfine
      Pages 125-142
    5. W. C. Duckworth
      Pages 143-165
  4. Insulin Receptor

    1. Front Matter
      Pages 167-167
    2. R. A. Roth
      Pages 169-181
    3. P. Rothenberg, M. F. White, C. R. Kahn
      Pages 209-236
    4. J. R. Levy, J. M. Olefsky
      Pages 237-266
    5. S. Jacobs
      Pages 267-286
  5. Effect of Insulin on Cellular Metabolism

    1. Front Matter
      Pages 287-287
    2. A. R. Saltiel, P. Cuatrecasas
      Pages 289-311
    3. J. Avruch, H. E. Tornqvist, J. R. Gunsalus, E. J. Yurkow, J. M. Kyriakis, D. J. Price
      Pages 313-366
    4. J. L. Messina
      Pages 399-419
    5. R. Bressler, J. J. Bahl
      Pages 451-467
  6. Back Matter
    Pages 469-476

About this book


It is fourteen years since insulin was last reviewed in The Handbook of Ex­ perimental Pharmacology, in volume 32. The present endeavor is more modest in scope. Volume 32 appeared in two separate parts, each having its own subeditors, and together the two parts covered nearly all areas of insulin pharmacology. Such comprehensiveness seemed impractical in a new volume. The amount of in­ formation related to insulin that is now available simply would not fit in a reasonable amount of space. Furthermore, for better or worse, scientists have be­ come so specialized that a volume providing such broad coverage seemed likely in its totality to be of interest or value to very few individuals. We therefore decided to limit the present volume to the following areas: insulin chemistry and structure, insulin biosynthesis and secretion, insulin receptor, and insulin action at the cellular level. We felt these areas formed a coherent unit. We also felt, perhaps as much because of our own interests and perspectives as any objective reality, that these were the areas in which recent progress has been most dramatic, and yet, paradoxically and tantalizingly, these were the areas in which most has yet to be learned. Even with this limited scope, there are some major gaps in coverage. Regrettably, two important areas, the beta cell ATP-sensitive potassium channel and the glucose transporter, were among these. Nevertheless, the authors who con­ tributed have done an excellent job, and we would like to thank them for their diligence.


Beta-Zelle Hormonrezeptor Insulin Zellmembran Zuckerkrankheit

Editors and affiliations

  • Pedro Cuatrecasas
    • 1
  • Steven Jacobs
    • 2
  1. 1.Pharmaceutical Research DivisionWarner Lambert CompanyAnn ArborUSA
  2. 2.Division of Cell BiologyBurroughs Wellcome Co.USA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1990
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-74100-5
  • Online ISBN 978-3-642-74098-5
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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