Microbial Resistance to Drugs

  • Lawrence E. Bryan

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 91)

Table of contents

  1. Front Matter
    Pages I-XVII
  2. D. J. Krogstad, P. H. Schlesinger, I. Y. Gluzman
    Pages 59-75
  3. A. A. Medeiros
    Pages 101-127
  4. C. C. Sanders
    Pages 129-149
  5. S. Chamberland
    Pages 151-167
  6. L. J. V. Piddock
    Pages 169-192
  7. L. P. Elwell, M. E. Fling
    Pages 249-290
  8. R. L. Then
    Pages 291-312
  9. W. V. Shaw, A. G. W. Leslie
    Pages 313-324
  10. D. E. Taylor
    Pages 325-357
  11. D. M. Shlaes, C. A. Currie-McCumber
    Pages 387-410
  12. Back Matter
    Pages 441-454

About this book


Most often when the subject of antimicrobial resistance is discussed, the organizational emphasis is on individual antimicrobial agents or groups of agents. Thus we tend to see discussion of resistance to f3-lactams, tetracyclines, amino­ glycosides etc. In this book many of the authors were asked to emphasize the mechanism of resistance in their discussion and from that to show how susceptibility to various agents was affected. In part this was done to help emphasize the enormous contribution that the study of antimicrobial resistance has made to our understanding of fundamental physiologic and genetic processes in bacteria. When one looks back over the study of antimicrobial resistance, it is clear that it has been the birthplace of many fundamental advances in molecular biology and of an appreciation of the role of many key functions in the life of a bacterium. In addition, and hopefully to an increasing extent in the future, such study has also contributed to advances in antimicrobial chemotherapy. Through­ out the book resistance mechanisms have been placed in perspective as to their significance as causes of resistance to key drugs or groups of drugs. Some are of much greater significance than others in terms of the prevalence or the degree of resistance produced. Whatever their numerical significance, however, each of the mechanisms, without question, throws light on fundamental cellular processes and the way in which they interact with antimicrobial agents.


antibiotic antibiotics genetics methylation microbes resistance

Editors and affiliations

  • Lawrence E. Bryan
    • 1
  1. 1.Department of Microbiology and Infectious Diseases, Faculty of MedicineUniversity of Calgary, Health Sciences CentreCalgaryCanada

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1989
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-74097-8
  • Online ISBN 978-3-642-74095-4
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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