© 1988

Mechanisms in B-Cell Neoplasia 1988

Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, March 23–25, 1988

  • Michael Potter
  • Fritz Melchers
Conference proceedings

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 141)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Pathogenetic Mechanisms

    1. Front Matter
      Pages 1-1
    2. Early B Cell Tumors

      1. R. A. Phillips, D.-D. Wu, G. M. Fulop
        Pages 11-15
      2. G. Lee, A. E. Namen, S. Gillis, P. W. Kincade
        Pages 16-18
      3. K. L. Holmes, J. S. Lee, H. C. Morse III
        Pages 19-26
      4. W. Y. Langdon, J. W. Hartley, S. P. Klinken, S. K. Ruscetti, H. C. Morse III
        Pages 27-30
      5. M. Principato, S. P. Klinken, J. L. Cleveland, U. R. Rapp, K. L. Holmes, J. H. Pierce et al.
        Pages 31-41
      6. E. H. Humphries, C. Frisch Barth, E. Pizer
        Pages 58-66
      7. P. E. Neiman, E. B. Gehly, L. M. Carlson, R. C. Cotter, C. B. Thompson
        Pages 67-74
      8. F. G. Haluska, G. Russo, M. Andreeff, C. M. Croce
        Pages 75-79
    3. B Cell and Plasma Cell Tumors

      1. A. W. Harris, W. Y. Langdon, W. S. Alexander, I. K. Hariharan, H. Rosenbaum, D. Vaux et al.
        Pages 82-93
      2. C. L. Sidman, J. D. Marshall, A. W. Harris
        Pages 94-99
      3. R. Dildrop, K. Zimmerman, R. A. DePinho, G. D. Yancopoulos, A. Tesfaye, F. W. Alt
        Pages 100-109
      4. J. Troppmair, M. Huleihel, J. Cleveland, J. F. Mushinski, J. Kurie, H. C. Morse III et al.
        Pages 110-114
      5. R. Clynes, L. W. Stanton, J. Wax, S. Smith-Gill, M. Potter, K. B. Marcu
        Pages 115-124
      6. B. Mock, J. Wax, R. Clynes, K. B. Marcu, M. Potter
        Pages 125-127

About these proceedings


The papers in this book were presented at the 6th Workshop on Mechanisms in B-Cell Neoplasia, held in Bethesda, March 23-25, 1988. On alternate years this meeting is sponsored by the . ;. Basel Institute of Immunology in Basel, Switzerland and by the National Cancer Institute in Bethesda, and is attended by 100 to 150 parti­ cipants. This 6th workshop, like the preceding five, was characterized by intense and enthusiastic discussion which reflects, we think, the exciting growth and development of this field. It is quite clear, however, that despite many general advances an understanding of the precise underlying mechanisms in B-cell tumor development is not yet defined. Probably, there is no single mechanism for all the various forms of B-cell neo­ plastic development. Many different forms of B-cell neoplasms are known, and these are distinguished by several characteristics: 1) the stage of development attained by the tumor stem cells; 2) mode of growth (slow or fast); 3) association with natural or inductive etiologic agents and 4) specific and consistent mutational mechanisms such as retroviral insertion, chromosomal rearrangement. Those charac­ teristic forms which arise naturally in relatively high frequency or those tumors with hallmark properties which can be induced consistently are the models most frequently studied, e. g. , endemic Burkitt's lymphoma, follicular lymphoma, acute and chronic lymphocytic leukemia and mUltiple myeloma in man; bursal lymphoma in chickens; Abelson virus induced pre B cell lymphomas and plasmacytomas in mice and immunocytomas in rats. Each model system, has special problems and advantages.


cell leukemia lymphoma mutation tumor virus

Editors and affiliations

  • Michael Potter
    • 1
  • Fritz Melchers
    • 2
  1. 1.Laboratory of Genetics National Institutes of HealthNational Cancer InstituteBethesdaUSA
  2. 2.Basel Institute for ImmunologyBaselSwitzerland

Bibliographic information

  • Book Title Mechanisms in B-Cell Neoplasia 1988
  • Book Subtitle Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, March 23–25, 1988
  • Editors Michael Potter
    Fritz Melchers
  • Series Title Current Topics in Microbiology and Immunology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1988
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-50212-8
  • Softcover ISBN 978-3-642-74008-4
  • eBook ISBN 978-3-642-74006-0
  • Series ISSN 0070-217X
  • Edition Number 1
  • Number of Pages XIV, 340
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Allergology
    Biochemistry, general
    Cancer Research
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