Molecular Basis of Viral and Microbial Pathogenesis

  • Rudolf Rott
  • Werner Goebel
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-IX
  2. H. L. Sänger, B. Haas
    Pages 1-20
  3. H.-D. Klenk, M. Tashiro, W. Garten, R. Rott
    Pages 25-38
  4. M. Mach, H. H. Niller, B. Fleckenstein
    Pages 51-59
  5. W. Doerfler, A. Spies, R. Jessberger, U. Lichtenberg, C. Zock, T. Rosahl
    Pages 60-72
  6. O. Haller, P. Staeheli
    Pages 95-101
  7. A. D. O’Brien, M. P. Jackson, L. R. M. Marques, N. A. Strockbine, D. L. Weinstein, M. A. Moore et al.
    Pages 102-108
  8. P. J. Sansonetti, B. Baudry, P. Clerc, A. T. Maurelli, X. Nassif, A. Ryter
    Pages 109-113
  9. V. A. Fischetti, K. F. Jones, S. Hollingshead, J. R. Scott
    Pages 123-131
  10. S. Bhakdi, J. Tranum-Jensen
    Pages 132-140
  11. S. Kathariou, J. Hacker, H. Hof, I. Then, W. Wagner, M. Kuhn et al.
    Pages 141-150
  12. V. Braun, E. Fischer, K. Hantke, H. Rotering
    Pages 151-159
  13. G. Harth, C. G. Haidaris, M. So
    Pages 176-185

About these proceedings


Elucidation of the mechanisms of pathogenesis underlying the diseases caused by viruses and bacteria has fascinated scientists for many years in two ways. Firstly, these pathogenic agents represent relatively sim­ ple biological systems for the study of basic biological processes such as replication, gene regulation, genetic variability and host-pathogen interactions. Secondly, process in this field is valuable in a practi­ cal sence, since it can help in the control of these diseases. The avail­ ability of new genetic and immunological techniques, especially recom­ binant DNA methods and monoclonal antibody technology, has provided powerful tools for unravelling the genetic, biochemical and immunologi­ cal basis of viral and microbial pathogenesis. Molecular cloning has allowed the isolation of single genes or groups of genes related to phenotypes which appear to be immunologically important for pathogene­ sis. The specific elimination of such genes from the complex genomes of the pathogens can now be achieved with similar genetic techniques. These genetic studies have provided additional information on the role played by specific phenotypic traits in pathogenesis, especially when combined with relevant animal model systems. Furthermore, the struc­ tural analysis of important virulence factors and surface antigens may allow the prediction of antigenic domains suitable for the development of new vaccines. The 38th Mosbacher Colloquium focuses on the molecular basis of viral and microbial pathogenesis. The virology part begins with the well­ studied plant viroids. The unusual structure of their genome, as well as knowledge about their replication and pathogenicity, are presented.


Toxin Trypanosoma cruzi Viruses Vivo glycoprotein leukemia virus molecular mechanisms protein proteins regulation virology virulence virus

Editors and affiliations

  • Rudolf Rott
    • 1
  • Werner Goebel
    • 2
  1. 1.Institut für Virologie der UniversitätGießenGermany
  2. 2.Institut für Genetik und Mikrobiologie der UniversitätWürzburgGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1988
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-73216-4
  • Online ISBN 978-3-642-73214-0
  • Series Print ISSN 0366-5887
  • Buy this book on publisher's site
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