© 1988

Local-spinal Therapy of Spasticity

  • Hermann Müller
  • Jan Zierski
  • Richard D. Penn
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Preface

    1. H. Müller, J. Zierski, R. D. Penn
      Pages 1-2
  3. A Short Historical Review of Spasticity and its Therapy

    1. D. Dralle, H. Müller, J. Zierski
      Pages 3-16
  4. Basic Experiences

    1. Front Matter
      Pages 17-17
    2. T. L. Yaksh, P. A. C. Durant, M. S. Monasky, C. W. Stevens, R. R. Schick
      Pages 19-36
    3. W. Zieglgänsberger, J. R. Howe, B. Sutor
      Pages 37-49
    4. H. Gerlach, H. Müller, J. Boldt, G. Hempelmann
      Pages 51-64
    5. U. Börner, H. Müller, J. Zierski, G. Hempelmann, M. Reinacher
      Pages 81-84
    6. J. Biscoping, G. Michaelis, D. Friess, D. Krauß, E. Mutschler, G. Hempelmann
      Pages 85-90
  5. Clinical Studies

    1. Front Matter
      Pages 91-91
    2. J. Noth
      Pages 93-96
    3. H. Müller, J. Zierski
      Pages 97-123
    4. D. L. Erickson, P. Moreno, J. Lo, J. Cameron, M. Michaelson
      Pages 137-142
    5. H. Müller, J. Zierski, D. Dralle, O. Hoffmann, G. Michaelis
      Pages 155-214
    6. H. Müller, J. Zierski, D. Dralle, D. Krauß, E. Mutschler
      Pages 223-226

About these proceedings


Historical photograph of spinal anaesthesia In 1884 the American neurologist J. L. eases. His discovery, however, marks the Corning, by blocking the neural con­ onset of the era of regional anaesthesia. It took almost one hundred years until his duction to the hind extremities of a dog by injecting cocaine-solution into the lumbar original idea of "local medication of the vertebral interspace, was the first to per­ cord" was again reconsidered due to two form spinal (or epidural?) anaesthesia [1]. reasons: At that time, he was unaware of the local I. The discovery of different drug receptors anaesthetic properties of cocaine (dis­ in the spinal cord made it possible, by in­ covered in the same year by C. Koller, who trathecal injection (or epidural appli­ cation, if the drug penetrates the dura), applied cocaine to the eye of one of his pa­ tients [3]) and did not intend to introduce to alter nociceptive or motor transmis­ an anaesthetic procedure. Corning's pri­ sion within the spinal cord. mary aim was the application of drugs in 2. Implantable devices for long-term appli­ proximity of the central nervous system, i. e. cation of drugs to specific sites of the spinal cord, in order to treat or even heal body, including the spinal spaces, were developed during the 1970's.


Infusion muscle neuropharmacology pain pharmacology pharmacotherapy rehabilitation spinal cord treatment

Editors and affiliations

  • Hermann Müller
    • 1
  • Jan Zierski
    • 2
  • Richard D. Penn
    • 3
  1. 1.Dept. Anesthesiology and Intensive Care MedicineJustus-Liebig-UniversityGießenGermany
  2. 2.Dept. NeurosurgeryJustus-Liebig-UniversityGießenGermany
  3. 3.Dept. NeurosurgeryRush-Presbyterian-St. Luke’s Medical Center Rush Medical CollegeChicagoUSA

Bibliographic information

Industry Sectors
Health & Hospitals