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The Reeler Mouse as a Model of Brain Development

  • Catherine Lambert de Rouvroit
  • André M. Goffinet

Part of the Advances in Anatomy Embryology and Cell Biology book series (ADVSANAT, volume 150)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Catherine Lambert de Rouvroit, André M. Goffinet
    Pages 1-26
  3. Catherine Lambert de Rouvroit, André M. Goffinet
    Pages 27-39
  4. Catherine Lambert de Rouvroit, André M. Goffinet
    Pages 59-71
  5. Catherine Lambert de Rouvroit, André M. Goffinet
    Pages 73-88
  6. Back Matter
    Pages 89-108

About this book

Introduction

Only five years ago, nobody in his right mind would have consid­ ered publishing a book on reeler as a model for brain develop­ ment. Although this interesting mutation has been with us for half a century, it is fair to say that, in spite of a wave of enthusiasm in the late sixties and early seventies, generated primarily by Sidman, Caviness and colleagues, studies of reeler mice fell pro­ gressively out of fashion during the next two decades. All that changed almost overnight when the cloning of the reeler gene, dubbed reelin, was reported in Tom Curran's laboratory in 1995. The fact that the same gene was identified at the same time independently by two other groups using positional cloning sug­ gested strongly that reelin was the right candidate. Although the key experiments of transgenic rescue have not been made (and perhaps will never be), the equation "reeler is reelin" has been established beyond reasonable doubt, as alterations of the reelin gene and/or its expression have been found in at least five alleles of reeler and in the mutation Shaking Rat Kawasaki (SRK), an ortholog of reeler.

Keywords

brain development brain malforation cortex phenotype reeler

Authors and affiliations

  • Catherine Lambert de Rouvroit
    • 1
  • André M. Goffinet
    • 1
  1. 1.Neurobiology UnitUniversity of Namur Medical SchoolNamurBelgium

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-72257-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1998
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-64674-7
  • Online ISBN 978-3-642-72257-8
  • Series Print ISSN 0301-5556
  • Series Online ISSN 2192-7065
  • Buy this book on publisher's site
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