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The Cerebral Perivascular Cells

  • D. N. Angelov
  • M. Walther
  • W. F. Neiss
  • M. Streppel
  • O. Guntinas-Lichius

Part of the Advances in Anatomy Embryology and Cell Biology book series (ADVSANAT, volume 147)

Table of contents

  1. Front Matter
    Pages I-XI
  2. D. N. Angelov, M. Walther, W. F. Neiss, M. Streppel, O. Guntinas-Lichius
    Pages 1-7
  3. D. N. Angelov, M. Walther, W. F. Neiss, M. Streppel, O. Guntinas-Lichius
    Pages 9-19
  4. D. N. Angelov, M. Walther, W. F. Neiss, M. Streppel, O. Guntinas-Lichius
    Pages 21-61
  5. D. N. Angelov, M. Walther, W. F. Neiss, M. Streppel, O. Guntinas-Lichius
    Pages 63-73
  6. D. N. Angelov, M. Walther, W. F. Neiss, M. Streppel, O. Guntinas-Lichius
    Pages 75-76
  7. Back Matter
    Pages 77-90

About this book

Introduction

Following an exhaustive literature review on the global issue of intracerebral presentation of antigen, this monograph summarizes results from voluminous work to establish which indigenous cerebral cells might present (auto)antigen to the immune system and thus initiate an (auto)immune reaction. Employing the combination of (a) a lesion model in which neuronal degeneration and neuronophagia are caused without disruption of the blood--brain barrier, (b) stable labeling of the neuronophages via phagocytosis of the permanent nontoxic fluorescent marker Fluoro-Gold from preloaded neurons, and (c) immunocytochemical identification of all FG-labeled brain neuronophages, the authors provide evidence that the only cells in the rat CNS which can be regarded as the resident antigen presenting cells of the brain are perivascular cells.

Keywords

Nervous System Neuronal degeneration antigen presentation central nervous system microglia migration neurons perivascular cells

Authors and affiliations

  • D. N. Angelov
    • 1
  • M. Walther
    • 1
  • W. F. Neiss
    • 1
  • M. Streppel
    • 2
  • O. Guntinas-Lichius
    • 2
  1. 1.Institut für Anatomie der Universität zu KölnKölnGermany
  2. 2.Klinik für Hals-, Nasen- und Ohrenheilkunde der Universität zu KölnKölnGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-72251-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1998
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-64638-9
  • Online ISBN 978-3-642-72251-6
  • Series Print ISSN 0301-5556
  • Series Online ISSN 2192-7065
  • Buy this book on publisher's site
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