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Leukocyte Integrins in the Immune System and Malignant Disease

  • Bernhard Holzmann
  • Hermann Wagner

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 231)

Table of contents

  1. Front Matter
    Pages I-VII
  2. C. Morimoto, S. Iwata, K. Tachibana
    Pages 1-22
  3. S. A. Michie, H.-K. Sytwu, J. O. McDevitt, X.-D. Yang
    Pages 65-83
  4. M. Isobe, J. Hori, J. Suzuki
    Pages 85-98
  5. A. R. Thomsen, A. Nansen, J. P. Christensen
    Pages 99-123
  6. B. Holzmann, U. Gosslar, M. Bittner
    Pages 125-141
  7. D. Naor, R. Vogt Sionov, M. Zahalka, M. Rochman, B. Holzmann, D. Ish-Shalom
    Pages 143-166
  8. Back Matter
    Pages 187-192

About this book

Introduction

Most lymphocytes recirculate throughout the body, migrating from blood through organized lymphoid tissues such as lymph nodes (LN) and Peyer's patches (PP), then to lymph and back to blood (GOWANS and KNIGHT 1964). Smaller numbers of lymphocytes migrate from blood to extranodal tissues such as pancreas and then through lymphatic vessels to LN (MACKAY et al. 1990). An important feature of this migration is the ability of lymphocytes to recognize and adhere to the surface of blood vessel endothelial cells before migrating through the vessel wall into surrounding tissue (CARLOS and HARLAN 1994; IMHOF and DUNON 1995; BUTCHER and PICKER 1996). Adhesion interactions of vascular endothelium with lymphocytes under flow or shear consist of at least four steps: (I) an initial transient sticking or rolling; (2) if the lymphocytes encounter appropriate activating or chemotactic factors in the local environment, rolling may be followed by a lymphocyte activation step that then leads to; (3) strong adhesion or sticking that may be followed by; (4) lym­ phocyte diapedesis into tissue (BUTCHER 1991; SHIMUZU et al. 1992; SPRINGER 1994; BARGATZE et al. 1995). Specific lymphocyte and endothelial adhesion molecules (AM) are involved in each step of this "adhesion cascade" (reviewed in CARLOS and HARLAN 1994; IMHOF and DUNON 1995; BUTCHER and PICKER 1996). This allows lymphocyte migration to be controlled at several different steps, leading to a combinatorial increase in specificity and sensitivity.

Keywords

Activation T cell cancer cell hematopoiesis immune system inflammation inflammatory response lymphoma metastasis migration molecular mechanisms regulation tumor virus

Editors and affiliations

  • Bernhard Holzmann
    • 1
  • Hermann Wagner
    • 1
  1. 1.Institute of Medical Microbiology, Immunology, and HygieneTechnical University of MunichMunichGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-71987-5
  • Copyright Information Springer-Verlag Berlin Heidelberg 1998
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-71989-9
  • Online ISBN 978-3-642-71987-5
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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