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Cyclin Dependent Kinase (CDK) Inhibitors

  • Peter K. Vogt
  • Steven I. Reed

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 227)

Table of contents

About this book

Introduction

More than 10 years ago, the discovery of cyclin-dependent ki­ nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control. Not only were both of the known cell cycle transitions, from G 1 to S phase and G2 to M phase, found to be dependent on these protein kinases, but the reg­ ulatory assumption intrinsic to cyclin-dependent kinases, a stable inactive catalytic subunit (the Cdk) and an unstable requisite positive regulatory activating subunit (the cyclin), led to a simple model for cell cycle control. Modulation of cyclin accumulation, and thereby Cdk activation, was proposed to be the overarching principle governing the passage through cell cycle phases. An­ other reality to emerge from the discovery of Cdks was the ex­ ceptional degree of evolutionary conservation maintained in the machinery and organization of proliferation control. Not only were Cdks shown to be structurally conserved between yeast and man, but mammalian Cdks could substitute functionally for the endogenous enzymes in a yeast cell. The problem of cell cycle control was thought to have been virtually solved. The ensuing years have provided a much more complex view of cell cycle control and the role and regulation of Cdks. The uncritical enthusiasm with which many of the ideas were em­ braced has required tempering. For example, although Cdks appear to be highly conserved phylogenetically, cyclins are much less so.

Keywords

CDK CKI Zellzyklus biochemistry biology cancer cell cell cycle cellular differentiation cellular growth cyclin-dependent kinase protein proteins regulation yeast

Editors and affiliations

  • Peter K. Vogt
    • 1
  • Steven I. Reed
    • 2
  1. 1.Division of Oncovirology, Department of Molecular and Experimental MedicineThe Scripps Research InstituteLa JollaUSA
  2. 2.Department of Molecular Medicine, MB-7The Scripps Research InstituteLa JollaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-71941-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 1998
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-71943-1
  • Online ISBN 978-3-642-71941-7
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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