© 1987

Mesenchymal-Epithelial Interactions in Neural Development

  • Joachim R. Wolff
  • Jobst Sievers
  • Martin Berry
Conference proceedings

Part of the NATO ASI Series book series (volume 5)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Molecular and Cell Biology of the Extracellular Matrix

    1. Front Matter
      Pages 1-1
    2. Y. Yamada, A. Albini, I. Ebihara, J. Graf, S. Kato, P. Killen et al.
      Pages 31-43
    3. R. Herken, Ch. Brandes, M. Fussek
      Pages 45-52
    4. R. U. Margolis, J. A. Ripellino, R. K. Margolis
      Pages 65-76
    5. Annie Delpech, Bertrand Delpech, Nicole Girard, Philippe Bertrand, Claude Chauzy
      Pages 77-87
  3. Mesenchymal-Epithelial Interaction in the Morphogenesis of Epithelial Organs

    1. Front Matter
      Pages 89-89
    2. P. Ekblom, E. Aufderheide, G. Klein, A. Kurz, A. Weller
      Pages 101-110
    3. Ursula Hahn, D. Schuppan, E. G. Hahn, H.-J. Merker, E.-O. Riecken
      Pages 111-117
    4. R. Schulz, D. Schuppan, E. G. Hahn
      Pages 119-125
    5. H. W. M. van Straaten, J. Drukker
      Pages 153-162
    6. J. Sievers, D. Hartmann, S. Gude, F. W. Pehlemann, M. Berry
      Pages 171-188
  4. Cell Proliferation, Growth and Differentiation

    1. Front Matter
      Pages 189-189
    2. D. Gospodarowicz, G. Neufeld
      Pages 191-221

About these proceedings


This book is based on the NATO Advanced Research Workshop on "Mesenchymal-Epithelial Interactions in Neural Development" which was held in Berlin during March 1986. The idea that it may be the time for this workshop arose from a discussion among the organizers who met at a conference in Innsbruck. During the twenties, Spemann demonstrated that, in vertebrates, the formation of neuroepithelium depends on the induction by specific mesodermal derivatives. This was about the first time that mesenchymal-epithelial interactions had been recognized as an important mechanism in the development of an epithelial organ. Since then two things had become clear: 1) The identity and role of molecules, elaborated at mesenchymal-neuroepithelial interfaces had been partially elucidated in spinal cord and peripheral nerve ontogeny but, until recently, had been ignored in studies on the development of the brain. 2) In many-non-neural epithelia, the surrounding mesenchyme regulates such fundamental developmental steps as, for example, cell proliferation, morphogenesis and cell differentia­ tion, and there is no reason to exclude similar influences and interactions from brain development. It seemed to us that the importance and implications of many of these findings had not been appreciated by many developmental neurobiologists and that an attempt should be made to initiate discussions and exchange of ideas among different groups of scientists involved in extracellular matrix (ECM) research. This turned out to be a formidable task because of the great diversity of disciplines contributing findings to this active field.


brain cell influence morphogenesis spinal cord

Editors and affiliations

  • Joachim R. Wolff
    • 1
    • 2
  • Jobst Sievers
    • 3
  • Martin Berry
    • 4
  1. 1.Berlin Institute for Advanced StudyZentrum AnatomieGöttingenGermany
  2. 2.Universität GöttingenZentrum AnatomieGöttingenGermany
  3. 3.Anatomiches InstitutUniversität KielKielGermany
  4. 4.Department of AnatomyGuy’s Hospital Medical SchoolLondonEngland

Bibliographic information

  • Book Title Mesenchymal-Epithelial Interactions in Neural Development
  • Editors Joachim R. Wolff
    Jobst Sievers
    Martin Berry
  • Series Title NATO ASI Series
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1987
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-17440-0
  • Softcover ISBN 978-3-642-71839-7
  • eBook ISBN 978-3-642-71837-3
  • Edition Number 1
  • Number of Pages XIV, 430
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Cell Biology
  • Buy this book on publisher's site
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