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Molecular Mechanisms of Desensitization to Signal Molecules

  • T. M. Konijn
  • H. Van der Wel
  • P. J. M. Van Haastert
  • M. D. Houslay
  • H. Van der Starre
Conference proceedings

Part of the NATO ASI Series book series (volume 6)

Table of contents

  1. Front Matter
    Pages N1-XIII
    PDF

  2. Chemotaxis and chemosensing

    1. Front Matter
      Pages 1-1
      PDF
    2. Behavioral Adaptation in Prokaryotes
      Robert M. Macnab
      Pages 3-13
    3. Surface Receptor Mediated Activation and Adaptation of Adenylate Cyclase in Dictyostelium discoideum
      Roxanne Vaughan, Maureen Pupillo, Anne Theibert, Peter Klein, Peter Devreotes
      Pages 15-24
    4. Adaptation of Dictyostelium Discoideum Cells to Chemotactic Signals
      Peter J. M. Van Haastert, René J. W. De Wit, Pim M. W. Janssens, Fanja Kesbeke, B. Ewa Snaar-Jagalska, Michiel M. Van Lookeren Campagne et al.
      Pages 25-42
    5. Adaptation, Periodic Signaling, and Receptor Modification
      Albert Goldbeter
      Pages 43-62

  3. Adenylate cyclase-coupled systems

    1. Front Matter
      Pages 63-63
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    2. Glucagon Desensitization of Adenylate Cyclase in Hepatocytes: An Action Mediated by a Distinct Population of Glucagon Receptors Coupled to Stimulate Inositol Phospholipid Metabolism
      Miles D. Houslay, Gregory J. Murphy, Clare M. Heyworth, Nigel J. Pyne, Michael J. O. Wakelam
      Pages 65-81
    3. Cellular Adaptation to Signal Molecules: Activation and Interaction of Different Signal Transduction Systems
      Karl H. Jakobs
      Pages 83-94
    4. Desensitization of the β-Adrenergic Coupled Adenylate Cyclase. The β-Adrenergic Receptor Kinase Phosphorylates Agonist-Occupied Cyclase-Coupled Receptors
      R. H. Strasser, J. L. Benovic, M. G. Caron, R. J. Lefkowitz
      Pages 95-115
    5. Structural Microheterogeneity of ß1-Adrenoceptors in Turkey Erythrocytes and Their Functional Consequences
      Fritz Boege, Rolf Jürß, Deirde Cooney, Mirko Hekman, Alan K. Keenan, Ernst J. M. Helmreich
      Pages 117-127
    6. Adaptive Response of Beta-Adrenergic Sensitive Adenylate Cyclase System
      V. Homburger, R. Bouhelal, C. Pantaloni, J. Bockaert
      Pages 129-146
    7. Hormone Specific Desensitization of Sertoli Cell Adenylate Cyclase in a Cell-Free System
      H. Attramadal, T. Jahnsen, V. Hansson
      Pages 147-160

  4. Inositol phospholipid-coupled systems

    1. Front Matter
      Pages 161-161
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    2. Adaptations of Receptor-Dependent Phosphatidylinositol 4,5-Bisphosphate Breakdown
      C. P. Downes, J. E. Merritt, P. T. Hawkins
      Pages 163-175
    3. Cell Responses to Phosphoinositide-Hydrolysing Receptors: Some Potential Sites of Modulation
      Colin W. Taylor
      Pages 177-195
    4. The Kinase C Substrate Protein B-50 and Feedback Control of Synaptic Signal Transduction
      W. H. Gispen, P. N. E. De Graan, A. B. Oestreicher, P. Schotman, L. H. Schrama, M. de Wit et al.
      Pages 197-211
    5. Retroinhibition of the Calcium-Phosphatidylinositol Cascade by Diacylglycerol in Thyroid
      J. E. Dumont, J. Mockel, P. Cochaux, I. Graff, E. Raspe, J. Van Sande
      Pages 213-222

  5. Visual transduction

    1. Front Matter
      Pages 223-223
      PDF
    2. Fast Termination and Adaptation Processes in the cGMP Cascade of Visual Transduction
      Marc Chabre, Joëlle Bigay, Philippe Deterre, Claude Pfister
      Pages 225-239
    3. Phosphorylation of Rhodopsin Involved in Terminating the Visual Response
      Hermann Kühn, Ursula Wilden
      Pages 241-254

  6. Ion conductance

    1. Front Matter
      Pages 255-255
      PDF
    2. Permeability Control and Desensitization by Nicotinic Acetylcholine Receptors
      Jonathan B. Cohen, Nina P. Strnad
      Pages 257-273

  7. Cellular systems

    1. Front Matter
      Pages 275-275
      PDF
    2. Regulation of Leukocyte Responses to Chemoattractants: Role of Receptors, Guanine Nucleotide Regulatory (N) Proteins and Phospholipase C
      Charles D. Smith, Margarith W. Verghese, Ralph Snyderman
      Pages 277-289
    3. Modulation of Macrophage Oxygen Metabolism
      G. Berton, M. A. Cassatella, E. A. Valletta
      Pages 291-300
    4. Antibody Induced Down Regulation of Membrane Receptors in Human Diseases
      F. Clementi, E. Sher
      Pages 301-317

  8. Concluding Remarks

    1. Front Matter
      Pages 319-319
      PDF
    2. Concluding Remarks
      Ernst J. M. Helmreich
      Pages 319-328
  9. Back Matter
    Pages 329-338
    PDF

About these proceedings

Keywords

Calcium Hormone Nucleotide activation antibody cell membrane metabolism molecular mechanisms phosphorylation protein proteins receptor regulation research

Editors and affiliations

  • T. M. Konijn
    • 1
  • H. Van der Wel
    • 2
  • P. J. M. Van Haastert
    • 1
  • M. D. Houslay
    • 3
  • H. Van der Starre
    • 4
  1. 1.Zoölogisch LaboratoriumLeidenThe Netherlands
  2. 2.RhoonThe Netherlands
  3. 3.Molecular Pharmacology Group, Department of BiochemistryUniversity of GlasgowGlasgowScotland
  4. 4.KennistransferUniversity of LeidenLeidenThe Netherlands

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-71782-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1987
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-71784-0
  • Online ISBN 978-3-642-71782-6
  • Buy this book on publisher's site
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