© 1986

Fibrin Sealant in Operative Medicine

Volume 5: Thoracic Surgery — Cardiovascular Surgery

  • Günther Schlag
  • Heinz Redl
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XVIII
  2. Principles of Fibrin Sealing

  3. Thoracic Surgery

About these proceedings


Fibrin plays a prominent role in wound healing. It has a hemostatic effect, induces cellular response to wound damage, and, by forming strands to build a matrix, assists in neovascularization and fibroblast proliferation. The concept of using clotting substances from human blood for wound manage­ ment and to achieve hemostasis in bleeding parenchymatous organs can be traced to 1909, when Bergel [1] reported on the hemostatic effect of fibrin powder. In 1915, Grey [3] employed fibrin to control bleeding in neurosurgical operations of the brain. A year later, Harvey [4] used fibrin patches to stop bleeding from parenchy­ matous organs in general surgery. It took more than two decades for this ingenious idea to be rediscovered. In 1940, Young and Medawar [8] reported on experimental nerve anastomosis by sealing. Similarly, Tarlov and Benjamin [7] reunited nerves with plasma clots in 1943. Tarlov improved the results obtained with clot anastomosing of nerves by avoiding tension at the nerve stumps. In 1944, Cronkite et al. [2] reported on an initial series of eight cases in which fibrinogen and thrombin had been used successfully for anchoring skin grafts.


aneurysm blood brain bypass cardiac surgery general surgery heart lung medicine plasma proliferation skin surgery thoracic surgery vascular surgery

Editors and affiliations

  • Günther Schlag
    • 1
  • Heinz Redl
    • 1
  1. 1.Ludwig-Boltzmann-Institut für experimentelle TraumatologieViennaAustria

Bibliographic information

  • Book Title Fibrin Sealant in Operative Medicine
  • Book Subtitle Volume 5: Thoracic Surgery — Cardiovascular Surgery
  • Editors G. Schlag
    H. Redl
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1986
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Softcover ISBN 978-3-540-17141-6
  • eBook ISBN 978-3-642-71633-1
  • Edition Number 1
  • Number of Pages XVIII, 222
  • Number of Illustrations 61 b/w illustrations, 0 illustrations in colour
  • Topics Thoracic Surgery
    Cardiac Surgery
    Vascular Surgery
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Surgery & Anesthesiology