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Table of contents

  1. Front Matter
    Pages i-vi
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. J. Doull
      Pages 3-9
    3. R. R. Maronpot, J. K. Haseman, G. A. Boorman, S. E. Eustis, G. N. Rao, J. E. Huff
      Pages 10-26
  3. Biology and Functional Properties of Mouse Liver Nodules

  4. Molecular Basis

    1. Front Matter
      Pages 109-109
    2. J. D. Hayes, R. E. Coulthwaite, P. K. Stockman, A. J. Hussey, T. J. Mantle, C. R. Wolf
      Pages 136-146
    3. P. Bentley, F. Bieri, F. Mitchell, F. Waechter, W. Stäubli
      Pages 157-161
    4. J. A. Swenberg, T. R. Fennell
      Pages 162-171
    5. F. Oesch, W. Aulmann, K. L. Platt, G. Doerjer
      Pages 172-179
  5. Modifying Factors

    1. Front Matter
      Pages 229-229
    2. A. E. Rogers, H. M. Nields, P. M. Newberne
      Pages 231-243
    3. C. F. Hollander, C. F. A. van Bezooijen, H. A. Solleveld
      Pages 244-250
    4. M. Metzler, G. H. Degen
      Pages 251-263
  6. Mouse and Human Liver Tumors

    1. Front Matter
      Pages 279-279
  7. Back Matter
    Pages 289-295

About these proceedings

Introduction

Peroxisome proliferation in the liver parenchymal cells is frequently observed in rats and mice exposed to certain xenobiotic compounds. Hepatic peroxisome pro­ liferation was first noted nearly twenty years ago in the livers of rats treated with the hypolipidemic drug clofibrate (Hess et aI. , 1965; Svoboda and Azarnoff, 1966). Subsequently, several structurally unrelated hypolipidemic compounds were found to induce marked hepatomegaly and hepatic peroxisome proliferation in rats and mice, which led to the suggestion of a possible relationship between peroxisome proliferation and lipid metabolism (Reddy and Krishnakantha, 1975) as well as to the identification of a peroxisomal fatty acid f3-oxidation enzyme sys­ tem in the rat liver (Lazarow and DeDuve 1976). A second major class of per ox i­ some proliferators was identified nearly ten years ago, with the discovery that the dietary administration of a widely used phthalate-ester plasticizer di(2-ethylhex­ yl)phthalate (DEHP) to rats, results in the induction of peroxisomal enzymes in liver (Reddy et aL 1976a). Hypolipidemic drugs and phthalate-ester plasticizers constitute two major and important categories of chemicals with profound peroxisome proliferative property (Reddy et aL 1982; Reddy and Lalwani 1983). These two classes of xenobiotics now have important roles. First, the hypolipi­ demic drugs are increasingly used in the control of hyperlipidemia, a major risk factor for developing coronary heart disease.

Keywords

drug lipide liver liver tumor metabolism xenobiotic xenobiotics

Editors and affiliations

  • Philip L. Chambers
    • 1
  • Dietrich Henschler
    • 2
  • Franz Oesch
    • 3
  1. 1.Department of Pharmacology and Therapeutics, Trinity CollegeUniversity of DublinDublin 2Ireland
  2. 2.Institut für Toxikologie und Pharmakologieder Universität WürzburgWürzburgGermany
  3. 3.Institut für Toxikologieder Universität MainzMainzGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-71617-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 1987
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-17124-9
  • Online ISBN 978-3-642-71617-1
  • Series Print ISSN 0171-9750
  • Buy this book on publisher's site
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