© 1986

Peptides as Immunogens

  • Hilary Koprowski
  • Fritz Melchers
Conference proceedings

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 130)

About these proceedings


The humoral response of the immune system to a foreign antigen usually requires the recognition of two antigenic determinants. The one, called the carrier, is recognized by T-Iymphocytes, the other, called the hapten, by B-Iympho­ cytes. As a consequence, T - and B-Iymphocytes proliferate, B-Iymphocytes produce hapten-specific antibodies, and the system develops memory to the antigens. It was long thought that antigens would form a bridge to mediate the cooperation of T - and B-Iymphocytes. However, it now appears that antigens are broken down to fragments which then act as carrier determinants for T -lymphocytes. The cells which originally process antigen are called an­ tigen-presenting cells. They have phagocytic properties. They can take up and degrade antigens, in the case of pro­ teins to peptides. The peptides of protein antigens reappear on the surface of the antigen-presenting cells, where they must become associated with membrane proteins encoded by genes of the major histocompatibility complex (MHC) in order to be recognized by T-Iymphocytes. To activate helper T-Iym­ phocytes which cooperate in antibody responses, MHC class II molecules have to be expressed on the surface of the antigen-presenting cells. Once T -lymphocytes have be­ come activated, they are ready to cooperate with B cells.


antibody antigen histocompatibility immune system lymphocytes protein proteins

Editors and affiliations

  • Hilary Koprowski
    • 1
  • Fritz Melchers
    • 2
  1. 1.The Wistar InstitutePhiladelphiaUSA
  2. 2.Institute for ImmunologyBaselSwitzerland

Bibliographic information

  • Book Title Peptides as Immunogens
  • Editors Hilary Koprowski
    Fritz Melchers
  • Series Title Current Topics in Microbiology and Immunology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1986
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-16892-8
  • Softcover ISBN 978-3-642-71442-9
  • eBook ISBN 978-3-642-71440-5
  • Series ISSN 0070-217X
  • Edition Number 1
  • Number of Pages X, 86
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Medical Microbiology
  • Buy this book on publisher's site
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