© 1986

HLA Class II Antigens

A Comprehensive Review of Structure and Function

  • Bjarte G. Solheim
  • Erna Møller
  • Soldano Ferrone

Table of contents

  1. Front Matter
    Pages I-XVII
  2. Molecular Biology

  3. Biochemistry

    1. H. Kratzin, H. Götz, F. P. Thinnes, T. Kruse, H. U. Barnikol, P. Wernet et al.
      Pages 49-70
    2. R. Sorrentino, G. Corte
      Pages 71-82
    3. M. Sanchez-Perez, S. Shaw
      Pages 83-108
  4. Genes Encoding Mouse Ia

  5. Cross-reaction Between Various Species

  6. Differences Between Ethnic Groups

    1. K. Tsuji, K. Sato, Y. Nose, H. Inoko, T. Nakatsuji, A. Ando et al.
      Pages 154-168
  7. Serological Definition

  8. Cellular Detection

  9. Regulation and Expression

    1. F. Ameglio, R. Tosi, N. Tanigaki, A. Dolei
      Pages 299-313
    2. H. Festenstein, L. Fainboim, D. Jaraquemada, C. Navarrete
      Pages 314-338

About this book


This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses. Trans­ plantation antigens were discovered and characterized by Gorer about 50 years ago, and the biological basis for the unequalled complexity of their variability between individuals within a species, in spite of extreme conservation between species, was the subject of intense research and discussion for many years. During the days of belief in "immune surveillance" against spontaneously developing tumors, it was suggested that histoincompatibility between members of one species would prevent cancer from being a contagious disease and thus a threat to the species. Immunologists involved in human transplantation had to learn and care about the complexity, especially after 1967, when it was found that HLA antigens were the products of the human MHC. Rejection of HLA-identical sib kidney grafts was so rare, even in those days, that cases of rejection were described in scientific papers.


Histokompatibilität T cell antibody antigen diseases genetics hematopoiesis histocompatibility immune response interferon lymphocytes molecular biology molecular genetics transplantation

Editors and affiliations

  • Bjarte G. Solheim
    • 1
  • Erna Møller
    • 2
  • Soldano Ferrone
    • 3
  1. 1.Blood Bank and Immunohematological LaboratoryRikshospitalet, National HospitalOslo 1Norway
  2. 2.Karolinska Institute, Department of Clinical ImmunologyHuddinge HospitalHuddingeSweden
  3. 3.Dept. of Microbiology and ImmunologyNew York Medical CollegeValhallaUSA

Bibliographic information

  • Book Title HLA Class II Antigens
  • Book Subtitle A Comprehensive Review of Structure and Function
  • Editors Bjarte G. Solheim
    Erna Moller
    Soldano Ferrone
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1986
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-15316-0
  • Softcover ISBN 978-3-642-70369-0
  • eBook ISBN 978-3-642-70367-6
  • Edition Number 1
  • Number of Pages XVIII, 564
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Allergology
  • Buy this book on publisher's site