Toxicology of Inhaled Materials

General Principles of Inhalation Toxicology

  • Hanspeter Witschi
  • Joseph D. Brain

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 75)

Table of contents

  1. Front Matter
    Pages I-XVII
  2. Exposure Techniques

  3. General Assessment of Toxic Effects

    1. Front Matter
      Pages 93-93
    2. P. J. Hakkinen, H. P. Witschi
      Pages 95-114
    3. Margaret R. Becklake
      Pages 115-147
    4. A. B. Fisher
      Pages 149-179
    5. B. T. Smith
      Pages 181-201
    6. J. D. Brain, Barbara D. Beck
      Pages 203-226
  4. Morphologic Techniques

    1. Front Matter
      Pages 227-227
    2. D. L. Dungworth, W. S. Tyler, C. E. Plopper
      Pages 229-258
    3. K. E. Pinkerton, J. D. Crapo
      Pages 259-285
  5. Biological and Biochemical Analysis

    1. Front Matter
      Pages 287-287
    2. I. Y. R. Adamson
      Pages 289-317
    3. Jennifer M. Sturgess
      Pages 319-367
    4. M. G. Mustafa
      Pages 369-419
    5. S. A. Rooney
      Pages 471-502
    6. J. A. Last, K. M. Reiser
      Pages 503-535
  6. Back Matter
    Pages 537-556

About this book


This book deals with the methods and scientific basis of inhalation toxicology. It describes devices and facilities needed to expose animals to inhaled particles and gases as well as approaches to estimating or measuring the fraction of the inhaled material that is retained in the respiratory tract. The book then reviews the evergrowing repertoire of techniques that can be used to measure the responses elicited by the exposure. Quantitative and qualitative anatomical, physiological, and biochemical strategies are discussed in detail. We believe that the toxicology of inhaled materials is an important and timely topic for several'reasons. During the past decade, morbidity and mortality attributable to cardiovascular disease have significantly decreased. Progress in combatting cancer, the second most important cause of death, has been slower, and lung cancer actually became the leading cause of death in men and the second leading cause of cancer death in women. In addition, the incidence of non-neo­ plastic respiratory diseases such as emphysema, fibrosis, and chronic bronchitis has increased the past decade. In the United States, the National Institutes of Health (NIH) has recently reported that chronic obstructive pulmonary disease affects nearly 10 miliion persons and accounts for 59,000 deaths yearly; indeed, it ranks as the fifth leading cause of death. Because the incidence is increasing, the NIH estimates that it may become the nation's fourth or even third leading cause of death by the year 2000.


Bronchitis Materials animals cancer cardiovascular disease kinetics particles toxicology

Editors and affiliations

  • Hanspeter Witschi
    • 1
  • Joseph D. Brain
    • 2
  1. 1.Toxicology, Biology DivisionOak Ridge National LaboratoryOak RidgeUSA
  2. 2.Department of Environmental Science and PhysiologyHarvard University School of Public HealthBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1985
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-69523-0
  • Online ISBN 978-3-642-69521-6
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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