The Origins of Depression: Current Concepts and Approaches

Report of the Dahlem Workshop on The Origins of Depression: Current Concepts and Approaches Berlin 1982, Oct.31 – Nov. 5

  • Editors
  • J. Angst
Conference proceedings

Part of the Dahlem Workshop Reports Life Sciences Research Report book series (DAHLEM, volume 26)

Table of contents

  1. Front Matter
    Pages i-x
  2. J. Angst
    Pages 1-3
  3. G. L. Klerman
    Pages 5-25
  4. P. J. Clayton
    Pages 77-89
  5. E. S. Paykel
    Pages 91-106
  6. R. J. Katz
    Pages 121-132
  7. G. W. Kraemer, M. H. Ebert, W. T. McKinney
    Pages 133-145
  8. E. S. Gershon, J. I. Nurnberger Jr., N. S. Nadi, W. H. Berrettini, L. R. Goldin
    Pages 187-204
  9. R. T. Rubin, R. E. Poland
    Pages 205-220
  10. D. J. Kupfer, C. F. Reynolds
    Pages 235-252
  11. D. von Zerssen
    Pages 253-271
  12. R. D. Porsolt
    Pages 313-330
  13. P. J. McGrath, D. F. Klein
    Pages 331-349
  14. H. Katschnig, J. Angst, P. J. Clayton, E. S. Gershon, M. Hautzinger, H. Helmchen et al.
    Pages 384-403
  15. M. L. Reite, T. F. Anders, W. Greil, D. Hellhammer, F. A. Henn, R. J. Katz et al.
    Pages 404-423
  16. S. A. Checkley, A. J. Rush, H. Beckmann, M. S. Buchsbaum, B. J. Carroll, J. F. Greden et al.
    Pages 424-445
  17. W. Z. Potter, H. Ågren, A. Carlsson, R. W. Cowdry, A. Delini-Stula, H. M. Emrich et al.
    Pages 446-457
  18. Back Matter
    Pages 458-472

About these proceedings


3 and a fraction mayor may not respond to treatment. On the behavioral level, animal research shows that a variety of experimental conditions can induce de­ pression. The same is true in the field of treatment, where pharmacologically highly different drugs can equally alleviate depression in animals and hu­ mans. The question as to whether this is due to a heterogeneity of depressive subjects based on different pathogenetic mechanisms is open to discussion. We can look for common features of all possible causal factors in the hope of finding a single basic mechanism. Many divergent findings may also be ex­ plained as peripheral changes of a highly complicated dynamic system. In the field of psychopharmacology, a circular reasoning has become evident in the sense that originally the clinical antidepressive response was founded on empirical grounds only. In a second step, an attempt was made to characterize some clinically active compounds pharmacologically, and in a third, further compounds were developed based on aspects of the pharmaco­ logical profiles. Moreover, the post hoc development of a pharmacological screening method has the serious disadvantage of delaying breakthroughs into new fields.


Angst Psychopharmakon Risikofaktor anxiety depression development drugs epidemiology pharmacology psychopharmacology research screening stress treatment

Bibliographic information

  • DOI
  • Copyright Information Dr. S. Bernhard, Dahlem Konferenzen, Berlin 1983
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-69131-7
  • Online ISBN 978-3-642-69129-4
  • Buy this book on publisher's site
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