Cyclic Nucleotides

Part I: Biochemistry

  • J. A. Nathanson
  • J. W. Kebabian

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 58 / 1)

Table of contents

  1. Front Matter
    Pages I-XX
  2. Biochemistry of Cyclic Nucleotides

    1. Front Matter
      Pages 1-1
    2. G. R. Revankar, R. K. Robins
      Pages 17-151
    3. L. Birnbaumer, R. Iyengar
      Pages 153-183
    4. C. K. Mittal, F. Murad
      Pages 225-260
    5. M. M. Appleman, M. A. Ariano, D. J. Takemoto, R. H. Whitson
      Pages 261-300
    6. W. Y. Cheung, D. R. Storm
      Pages 301-323
    7. C. L. Kapoor, A. L. Steiner
      Pages 333-354
  3. Biochemistry of Protein Phosphorylation

    1. Front Matter
      Pages 355-355
    2. P. Greengard
      Pages 357-361
    3. J. A. Beavo, M. C. Mumby
      Pages 363-392
    4. J. F. Kuo, M. Shoji
      Pages 393-424
    5. H. Schulman
      Pages 425-478
  4. Back Matter
    Pages 535-557

About this book


The purpose of the present volume, the first of two on the pharmacology, biochemistry, and physiology of cyclic nucleotides, is to provide a comprehensive and up-to-date anthology on the nature and role of these important chemical regulators. Each of the chapters is the work of internationally known researchers who present a lucid and detailed review of their subject and not merely a single laboratory's viewpoint. The chapters emphasize critical assessments of the field rather than mere listings of experimental findings. By so doing, the contributors present the role of cyclic nucleotides in relationship to other intracellular regulators. Each chapter begins with a detailed summary to allow the reader to obtain a rapid overview of subsequent material. In addition, there are extensive bibliographies and a detailed subject index. Wherever pertinent, the chapters contain sections on drug mechanisms, physiological relevance, and disease processes. The Volume is divided into two sections, each beginning with an overview written by Professors T. W. RALL and P. GREENGARD, respectively. The first section focuses on the detailed pharmacology and chemistry of cyclic nucleotides, including their formation, degradation, measurement, and interaction with various modulatory agents, such as receptors and calcium. The second section is concerned with the biochemistry of protein phosphorylation, a process which appears to be one of the most important mechanisms for the intracellular expression of cyclic nucleotide action in eukaryotic cells.


Calcium Nucleotide biochemistry chemistry drug pharmacology phosphorylation physiology protein receptor research

Editors and affiliations

  • J. A. Nathanson
    • 1
  • J. W. Kebabian
    • 2
  1. 1.Neuropharmacology Research Laboratory, Departments of Neurology and PharmacologyHarvard Medical School, Massachusetts General HospitalBostonUSA
  2. 2.Biochemical Neuropharmacology UnitNINCDS National Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1982
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-68113-4
  • Online ISBN 978-3-642-68111-0
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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