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© 1981

Nitrates III

Cardiovascular Effects

  • P. R. Lichtlen
  • H.-J. Engel
  • A. Schrey
  • H. J. C. Swan
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XXI
  2. Basic Action of Nitrates

    1. Front Matter
      Pages 1-1
    2. M. G. Bogaert, M. T. Rosseel, O. Teirlynck
      Pages 23-26
    3. J. O. Parker, U. Thadani
      Pages 27-36
    4. P. R. Lichtlen, H.-J. Engel, A. Schrey, H. J. C. Swan
      Pages 37-38
  3. Pharmacodynamics and Kinetics

    1. Front Matter
      Pages 39-39
    2. T. Taylor, L. F. Chasseaud
      Pages 40-46
    3. L. F. Chasseaud, T. Taylor
      Pages 47-53
    4. W. Rudolph, R. Blasini, K.-L. Froer, U. Bruegmann, A. Mannes, D. Hall
      Pages 75-81
    5. A. Distante, A. L’Abbate, C. Palombo, C. Michelassi, D. Rovai, M. A. Morales et al.
      Pages 82-90
    6. B. Pitt, H. Colfer, A. Keith, P. Stetson, J. Walton, J. Brymer et al.
      Pages 91-94
    7. W. H. Down, L. F. Chasseaud, S. A. Ballard
      Pages 110-116

About these proceedings

Introduction

Pharmacological and clinical research on nitrates continues to be of growing interest in many centers. This is surprising in view of the fact that their favorable effects in angina pectoris were described by Brunton and by Murrell in the Lancet more than 100 years ago. As expected, a host of new information has been collected since the two previous symposia on nitrates held in Stockholm in 1975 and Berlin in 1978. New insights were gained into the pharmacology, pharmacokinetics and pharmacodynamics of nitrates, as well as into their clinical effects in acute and chronic ischemic heart diseases and in severe congestive heart failure. Relatively little progress, however, was observed in research into the basic action of nitrates. Although most investigators agree that intracellular sequestration of calcium is probably the main mechanism by which nitrates lead to the reduction of vascular smooth muscle tone, the exact site of their action still remains undefined. In contrast, dose-dependent differences in venous and arteriolar tone have long been clearly established. Treatment was again in the main stream of discussion. The question of tolerance following long-term administration was discussed in depth and the term "pseudotolerance" was introduced to describe the adaptation of the body's circulatory system to chronic vasodilation. This is especially important in long term prophylactic antiischemic treatment in stable, as well as in unstable angina pectoris (i.e. during increased vasomotor tone - spasm).

Keywords

Herz-Kreislauf-System Nitrat Nitrates angina pectoris calcium circulation clinical research heart kinetics lead pharmacodynamics pharmacokinetics research

Editors and affiliations

  • P. R. Lichtlen
    • 1
  • H.-J. Engel
    • 2
  • A. Schrey
    • 3
  • H. J. C. Swan
    • 4
  1. 1.Abteilung für KardiologieMed. Hochschule HannoverHannover 61Germany
  2. 2.Zentralkrankenhaus „Links der Weser“Bremen 61Germany
  3. 3.Pharma-Schwarz GmbHMonheimGermany
  4. 4.Dept. of CardiologyCedars-Sinai Medical CenterLos AngelesUSA

Bibliographic information

  • Book Title Nitrates III
  • Book Subtitle Cardiovascular Effects
  • Editors P. Lichtlen
    H.-J. Engel
    A. Schrey
    H.J.C. Swan
  • DOI https://doi.org/10.1007/978-3-642-68085-4
  • Copyright Information Springer-Verlag Berlin Heidelberg 1981
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-10761-3
  • Softcover ISBN 978-3-642-68087-8
  • eBook ISBN 978-3-642-68085-4
  • Edition Number 1
  • Number of Pages XXII, 600
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Cardiology
    Pharmacology/Toxicology
  • Buy this book on publisher's site
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